{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T17:40:46Z","timestamp":1785865246143,"version":"3.56.0"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T00:00:00Z","timestamp":1558569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Universidad Autonoma de Sinaloa-PROFAPI","award":["PROFAPI2014\/225"],"award-info":[{"award-number":["PROFAPI2014\/225"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vitiligo is an acquired pigmentation disorder characterized by melanocyte loss via autoimmune mechanisms triggered by oxidative stress. Gene polymorphisms in antioxidant enzymes and immunomodulators such as catalase (<jats:styled-content style=\"fixed-case\">CAT<\/jats:styled-content>) and vitamin D receptor (<jats:styled-content style=\"fixed-case\">VDR<\/jats:styled-content>), respectively, have been linked to vitiligo in European and Asian populations. Our aim was to evaluate the role of<jats:styled-content style=\"fixed-case\">CAT<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">VDR<\/jats:styled-content>gene polymorphisms as well as CAT and vitamin D in nonsegmental vitiligo in Northwestern Mexicans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 357 subjects, 173 nonsegmental vitiligo patients and 184 age\u2010gender\u00a0matched healthy controls, were genotyped by<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\u2010restriction fragment length polymorphism.<jats:styled-content style=\"fixed-case\">CAT<\/jats:styled-content>activity was determined in 39 patients and in 39 controls and vitamin D (VitD) levels in 35 individuals per group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CAT<\/jats:styled-content>419 C\/T gene polymorphism was not informative, \u201089 A\/T was associated with risk (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02), and 389 C\/T conferred protection against vitiligo\u00a0along with<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>haplotype (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01 in both cases).<jats:styled-content style=\"fixed-case\">VDR<\/jats:styled-content><jats:italic>Bsm<\/jats:italic>I,<jats:italic>Apa<\/jats:italic>I, and<jats:italic>Taq<\/jats:italic>I gene polymorphisms were not associated with vitiligo, but<jats:italic>Bsm<\/jats:italic>I was more prevalent in patients with Koebner phenomenon (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02). Serum<jats:styled-content style=\"fixed-case\">CAT<\/jats:styled-content>activity and VitD levels were lower in patients than in controls, but they showed no association with any vitiligo clinical characteristics neither with their gene polymorphisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest a role for<jats:styled-content style=\"fixed-case\">CAT<\/jats:styled-content>gene polymorphisms in vitiligo susceptibility in the Mexican population and a lack of association with<jats:styled-content style=\"fixed-case\">VDR<\/jats:styled-content>gene polymorphisms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14508","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T10:10:56Z","timestamp":1558606256000},"page":"1264-1269","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Catalase but not vitamin D receptor gene polymorphisms are associated with nonsegmental vitiligo in Northwestern Mexicans"],"prefix":"10.1111","volume":"58","author":[{"given":"Luis A.","family":"Ochoa\u2010Ram\u00edrez","sequence":"first","affiliation":[{"name":"Facultad en Ciencias Qu\u00edmico Biol\u00f3gicas Universidad Aut\u00f3noma de Sinaloa (UAS) Culiac\u00e1n Sinaloa M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia P.","family":"D\u00edaz\u2010Camacho","sequence":"additional","affiliation":[{"name":"Unidad de Investigaciones en Ambiente y Salud Universidad Aut\u00f3noma de Occidente Culiac\u00e1n Sinaloa M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denisse S.","family":"Becerra\u2010Loaiza","sequence":"additional","affiliation":[{"name":"Facultad en Ciencias Qu\u00edmico Biol\u00f3gicas Universidad Aut\u00f3noma de Sinaloa (UAS) Culiac\u00e1n Sinaloa 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