{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:07:18Z","timestamp":1790381238066,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T00:00:00Z","timestamp":1559260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Vitiligo is a refractory disease in which treatment modalities are not yet established. We aim to assess results obtained 10\u00a0years after the initiation of\u00a0a therapeutic protocol which combines very potent topical corticosteroids (<jats:styled-content style=\"fixed-case\">TCS<\/jats:styled-content>), vitaminotherapy (B12 and C), and suppression of microtraumas in the management of nonsegmental vitiligo in Madagascar.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>It was a prospective and descriptive study over a period of 6\u00a0years (2011\u20132016) in the Department of Dermatology, Joseph Raseta Befelatanana, Antananarivo, Madagascar. The diagnosis of vitiligo was based on clinical data. Patients who agreed to follow the treatment protocol, which combined very potent <jats:styled-content style=\"fixed-case\">TCS<\/jats:styled-content> (two applications\/day for 10\u00a0days, and then one application\/day for the following 10\u00a0days), oral vitamin C 500\u00a0mg\/day for 20\u00a0days, and oral vitamin B12 100\u00a0mg\/day for 20\u00a0days, were included in the study. Two successive courses of treatment were made 10\u00a0days apart.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The details of 308 vitiligo patients were analyzed. The mean age of patients was 33.3\u00a0years. There was a female preponderance (sex ratio: 0.6). The duration of treatment in our patients varied from 3 to 18\u00a0months. Two hundred and thirty\u2010nine patients had good therapeutic compliance and attended regular follow\u2010up. Excellent repigmentation (more than 76% area repigmented) was noted in 50 patients (65.7%) less than 14\u00a0years\u00a0of age. Lesions evolving in\u00a0less than 1\u00a0year in 31 patients (36.9%) had excellent response to treatment. Localized lesions responded favorably to treatment with excellent repigmentation in 108 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results show that therapeutic response is better in young people, lesions less than 1\u00a0year of evolution, and for localization of vitiligo in the face and neck.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14510","type":"journal-article","created":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T07:56:22Z","timestamp":1559289382000},"page":"908-911","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Treatment responses in patients with vitiligo to very potent topical corticosteroids combined with vitaminotherapy in Madagascar"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2606-3539","authenticated-orcid":false,"given":"Fandresena A.","family":"Sendrasoa","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital Joseph Raseta Befelatanana Antananarivo Madagascar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina M.","family":"Ranaivo","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Morafeno Toamasina Madagascar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moril","family":"Sata","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Joseph Raseta Befelatanana Antananarivo Madagascar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malalaniaina","family":"Andrianarison","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Joseph Raseta Befelatanana Antananarivo 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Madagascar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahafahantsoa","family":"Rapelanoro Rabenja","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Joseph Raseta Befelatanana Antananarivo Madagascar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60763-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000354607"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163806"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2005.02814.x"},{"key":"e_1_2_6_6_1","first-page":"19","article-title":"Epidemiological survey on vitiligo in Jiaozuo district, Henan province","volume":"4","author":"Pei GD","year":"2011","journal-title":"J Pract 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