{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:14:52Z","timestamp":1747185292325,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T00:00:00Z","timestamp":1560902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lichen planus (LP) is an inflammatory disease that affects skin, hair follicles, mucous membranes, and nails. Ki\u201067 is an antigen associated with the proliferation of cells in all stages of cell cycle except G0. Bcl\u20102 is a protooncogene that protects cells from apoptosis. COX\u20102 is an antiapoptotic protein that increases in inflammation. The infiltration of T cells in LP seems to be responsible in the apoptosis of the basal keratinocytes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of this study was to investigate the effects of prednisolone and acitretin treatments on Ki\u201067, Bcl\u20102, and COX\u20102 expression and apoptosis in patients with LP and the role of Ki\u201067, Bcl\u20102, and COX\u20102 proteins in LP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010eight patients with clinically and histopathologically diagnosed LP who had not been treated with systemic treatment before and 15 healthy volunteers were evaluated prospectively. Pretreatment and posttreatment biopsies were immunohistochemically stained with Ki\u201067, Bcl\u20102, and COX\u20102. The percentage of the stained cells were calculated and recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although the percentage of staining with Ki\u201067 and Bcl\u20102 after treatment with prednisolone and acitretin decreased significantly (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) in both groups, there was no significant difference between groups (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05). COX\u20102 decreased but was not statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>With this study in cutaneous lichen planus, prednisolone and acitretin treatments reduced Bcl\u20102 and Ki\u201067 levels and did not effect COX\u20102 levels. It should be clarified whether these results can be obtained with any treatment effective in cutaneous lichen planus.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14543","type":"journal-article","created":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T04:33:43Z","timestamp":1561005223000},"page":"1444-1450","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Immunohistochemical evaluation of the effect of acitretin and systemic steroid treatments on Ki\u201067, Bcl\u20102, and COX\u20102 levels in cutaneous lichen planus patients"],"prefix":"10.1111","volume":"58","author":[{"given":"Murat","family":"Ozturk","sequence":"first","affiliation":[{"name":"Department of Dermatology Health Sciences Universty, Van Training and Research Hospital Van Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goknur","family":"Ozayd\u0131n Yavuz","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Yuzuncu Yil Universty Van Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130brahim H.","family":"Yavuz","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Yuzuncu Yil Universty Van Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remzi","family":"Erten","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine Yuzuncu Yil Universty Van Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serap","family":"Gunes Bilgili","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Yuzuncu Yil Universty Van Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3366-4551","authenticated-orcid":false,"given":"Isa","family":"An","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sanliurfa Education and Research Hospital Sanliurfa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10882.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jssdds.2013.12.003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013216"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13416"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.04062.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.5114\/pdia.2016.56930"},{"key":"e_1_2_7_8_1","first-page":"233","volume-title":"The Role of Apoptosis in Psoriasis and Lichen Planus. Focus on Cell Apoptosis Research\/Daniel W. Cho (ur.)","author":"Ka\u0161telan M","year":"2007"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.12031_suppl"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12279"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-010-1046-3"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4652(200003)182:3<371::AID-JCP8>3.0.CO;2-J"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2184.35.s1.11.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01508.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.5856"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199702000-00009"},{"key":"e_1_2_7_17_1","first-page":"903","article-title":"The role of cyclooxygenase\u20102 and prostaglandin E2 in the pathogenesis of cutaneous lichen planus","volume":"40","author":"El\u2010Rifaie AA","year":"2015","journal-title":"ClinExpDermatol"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-6980(02)00029-1"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2013.07.003"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.5114\/pjp.2013.36006"},{"key":"e_1_2_7_21_1","first-page":"411","article-title":"Expression of COX\u20102 and bcl\u20102 in oral lichen planus lesions and lichenoid reactions","volume":"8","author":"Arreaza AJ","year":"2014","journal-title":"Ecancermedicalscience"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2008.03029.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01821.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2006.06.007"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-007-0117-0"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04274.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2004.00244.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2007.03099.x"},{"key":"e_1_2_7_29_1","first-page":"235","article-title":"Estimation of malignant transformation rate in cases of oral epithelial dysplasia and lichen planus using immunohistochemical expression of Ki\u201067, p53, BCL\u20102, and BAX markers","volume":"12","author":"Shailaja G","year":"2015","journal-title":"Dent Res J"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2010.08.005"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jds.2015.12.002"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.14543","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.14543","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijd.14543","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.14543","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T18:45:52Z","timestamp":1694198752000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.14543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,19]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/ijd.14543"],"URL":"https:\/\/doi.org\/10.1111\/ijd.14543","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"type":"print","value":"0011-9059"},{"type":"electronic","value":"1365-4632"}],"subject":[],"published":{"date-parts":[[2019,6,19]]},"assertion":[{"value":"2018-09-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}