{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:35:02Z","timestamp":1762324502235,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,6,23]],"date-time":"2019-06-23T00:00:00Z","timestamp":1561248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lichen planus (LP) is an inflammatory skin disorder of unknown etiology. Chitinase\u20103\u2010like protein 1 (YKL\u201040) is a multifunctional proinflammatory protein, which has an important role not only in immunity and inflammation, but also in the regulation of cell proliferation, differentiation, and apoptosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim of the work<\/jats:title><jats:p>The present study was designed to investigate the serum level of YKL\u201040 in patients with different clinical presentations of LP in comparison to healthy participants in order to study its possible role in the pathogenesis of LP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>A total of 60 consecutive subjects were enrolled in this prospective case\u2010control study including 30 patients with different clinical variants of LP (16 male and 14 female patients) in addition to 30 healthy controls matched for age and gender. The serum level of serum YKL\u201040 was evaluated by means of ELISA method in both patients and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The serum YKL\u201040 level was significantly higher (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) in patients than in controls. Also, significantly higher levels were found in patients with oral type than in patients with cutaneous type who do not have oral lesions (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). The sensitivity and specificity of serum YKL\u201040 were 62.5 and 81.8%, respectively, (cut off value of 151\u00a0pg\/ml) for the diagnosis of oral lesions in LP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings in our study support the role of YKL\u201040 in the pathogenic process of LP and may help in treatment of lichen planus.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14551","type":"journal-article","created":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T04:34:11Z","timestamp":1561350851000},"page":"993-996","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Chitinase\u20103\u2010like protein 1 (YKL\u201040): novel biomarker of lichen planus"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2600-4021","authenticated-orcid":false,"given":"Fathia M.","family":"Khattab","sequence":"first","affiliation":[{"name":"Dermatology, Venereology, and Andrology Departments, Faculty of Medicine Zagazig University Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora M.","family":"Said","sequence":"additional","affiliation":[{"name":"Lecturer of Clinical Pathology Department, Faculty of Medicine Zagazig University Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,23]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"296","volume-title":"Fitzpatrick's Dermatology in General Medicine","author":"Daoud MS","year":"2012"},{"key":"e_1_2_6_3_1","first-page":"1090","volume-title":"IADVL Text Book of Dermatology","author":"Rao R","year":"2015"},{"key":"e_1_2_6_4_1","first-page":"1","volume-title":"Rook's Textbook of Dermatology","author":"Piguet V","year":"2016"},{"key":"e_1_2_6_5_1","first-page":"742826","article-title":"Cutaneous and mucosal lichen planus: a comprehensive review of clinical subtypes, risk factors, diagnosis, and prognosis","volume":"2014","author":"Farzam G","year":"2014","journal-title":"Sci World J"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09235.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.159624"},{"key":"e_1_2_6_8_1","first-page":"1","article-title":"Metabolic derangements in lichen planus \u2010 A case control study","volume":"10","author":"Kar BR","year":"2016","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"304","DOI":"10.4103\/idoj.IDOJ_27_18","article-title":"Prevalence of metabolic syndrome in patients with lichen planus: a cross\u2010sectional study from a tertiary care center","volume":"9","author":"Hashba H","year":"2018","journal-title":"Indian Dermatol Online J"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.4103\/idoj.IDOJ_48_18","article-title":"comorbidities in lichen planus: a case\u2010control study in Indian patients","volume":"10","author":"Kumar SA","year":"2019","journal-title":"Indian Dermatol Online J"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.107.075846"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-012110-142250"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0011"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2011.06.012"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12061"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-014-2277-y"},{"key":"e_1_2_6_17_1","first-page":"167","article-title":"Atherosclerosis, some serum inflammatory markers in psoriasis. 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