{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T15:13:03Z","timestamp":1785683583932,"version":"3.56.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T00:00:00Z","timestamp":1571616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Less than 5% of cases of mycosis fungoides (MF) present with a cytotoxic\/suppressor CD8<jats:sup>+<\/jats:sup> phenotype. This study aimed to evaluate the clinical characteristics, treatment modalities, and clinical course in CD8<jats:sup>+<\/jats:sup> MF patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a retrospective analysis of 353 MF patients in a referral center at Ankara University, Turkey, 29 patients that were diagnosed with CD8<jats:sup>+<\/jats:sup> MF were included in the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CD8<jats:sup>+<\/jats:sup> MF cases constituted 8.2% of all MF patients. The age at the time of diagnosis ranged between 6 and 81\u00a0years with a median value of 46\u00a0years. The female\u2010to\u2010male ratio was 1.41. Patients presented with erythematous scaly (69%), hyperpigmented (58.6%), poikilodermic (17.2%), and hypopigmented (17.2 %) patches\/plaques. The most common sites of involvement were the trunk and lower extremities. The most common comorbidity was hypertension (24.1%, <jats:italic>n<\/jats:italic>: 7) with 13 patients (44.8%) having a history of at least one autoimmune disease. At the time of diagnosis, 93.2% of the patients had early\u2010stage disease, and 6.8% of the patients had advanced stage. The mean follow\u2010up period was 6.68\u00a0\u00b1\u00a06.04\u00a0years (range 1\u201328\u00a0years). Most of the patients were treated with skin\u2010directed therapies. Complete remission was achieved in 17 (58.6%) patients, eight (27.6%) patients had partial remission, and four (13.8%) patients had stable disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We concluded that CD8<jats:sup>+<\/jats:sup> MF is associated with an indolent course and in most patients, skin\u2010directed therapies were found to be efficient to control the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14689","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T14:29:46Z","timestamp":1571668186000},"page":"127-133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["CD8<sup>+<\/sup> cytotoxic mycosis fungoides: a retrospective analysis of clinical features and follow\u2010up results of 29 patients"],"prefix":"10.1111","volume":"59","author":[{"given":"Incilay","family":"Kalay Yildizhan","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Ankara University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatice","family":"Sanli","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Ankara University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengu N.","family":"Akay","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Ankara University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ece","family":"S\u00fcrg\u00fcn","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Ankara University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aylin","family":"Heper","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine Ankara University Ankara 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