{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:15:06Z","timestamp":1747185306757,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T00:00:00Z","timestamp":1572393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Polish Ministry of Science and Higher Education","award":["02-0066\/07"],"award-info":[{"award-number":["02-0066\/07"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mycosis fungoides (MF) skin lesions are characterized by low\u2010grade inflammation, which may be sustained by proinflammatory cytokines as probably interleukin\u201033 (IL\u201033). We compared serum concentrations of IL\u201033 and its receptor ST2 and the frequency of selected IL\u201033 single nucleotide polymorphisms (SNPs) between patients with MF and healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 88 patients with MF and 66 healthy controls, we analyzed SNPs in the 9894 and 11877 loci of the<jats:italic>IL\u201033<\/jats:italic>gene. Moreover, we measured serum concentrations of IL\u201033 and its receptor ST2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no statistically significant differences in the frequencies of both IL\u201033 SNPs between patients and controls. Compared with controls, patients with MF had similar IL\u201033 serum concentrations (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.71) but significantly increased ST2 concentrations (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Patients in MF\u2010IA stage had significantly lower ST2 serum concentrations than those with the remaining MF stages (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002). The studied variables were not related to pruritus severity. Patients with the C(+) IL\u201033 11877 SNP had lower ST2 serum concentrations than patients with the C(\u2212) 11877 SNP (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.043).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>It was published before that the knockout of the<jats:italic>ST2<\/jats:italic>gene after injection of IL\u201033 is associated with a reduced inflammatory reaction in the skin, as well as that IL\u201033 plays a role in allergic and neoplastic disorders. Concerning the difference in ST2 concentration between control and MF group, and C IL\u201033 11877 SNP possibly influencing the ST2 concentration, the role of IL\u201033\/ST2 signaling, needs further studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14696","type":"journal-article","created":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T08:59:00Z","timestamp":1572425940000},"page":"345-351","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Interleukin\u201033 polymorphisms and serum concentrations in mycosis fungoides"],"prefix":"10.1111","volume":"59","author":[{"given":"Alicja","family":"Rustowska\u2010Rogowska","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology Medical University of Gdansk Gdansk Poland"},{"name":"Medpharma CRL Nowa Wie\u015b Rzeczna 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