{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:22:32Z","timestamp":1789456952471,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,10,20]],"date-time":"2019-10-20T00:00:00Z","timestamp":1571529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Several case reports and case series have recently explored the association between hidradenitis suppurativa (HS) and inflammatory bowel disease (IBD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We performed a systematic review and meta\u2010analysis of case\u2010control studies to determine\u00a0 (i) the pooled prevalence of IBD in HS cohorts, and (ii) whether HS is more strongly associated with Crohn\u2019s disease or ulcerative colitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Electronic searches were performed using five databases, from their inception to August 2018. Case\u2010control studies reporting the proportion of IBD cases in HS cohorts were included and meta\u2010analysis performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From six included studies, a significant association between HS and IBD after pooling of adjusted effect sizes was identified (OR 2.12; 95% CI 1.62\u20132.77; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03). Subgroup analysis demonstrated a significant association between HS and Crohn\u2019s disease (OR 2.25; 95% CI 1.52\u20133.32; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001, <jats:italic>I<\/jats:italic><jats:sup>2\u00a0<\/jats:sup>=\u00a092%) and with ulcerative colitis (OR 1.56; 95% CI 1.26\u20131.94; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001; <jats:italic>I<\/jats:italic><jats:sup>2\u00a0<\/jats:sup>=\u00a036%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations<\/jats:title><jats:p>Studies reviewed were observational by design which are susceptible to bias and lack of randomization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results indicate a statistically significant association between HS and IBD. Our results highlight that all patients with HS should be clinically screened for symptoms of IBD and symptomatic patients referred for further investigations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14697","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T05:54:14Z","timestamp":1571637254000},"page":"221-228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Prevalence of inflammatory bowel disease (IBD) in hidradenitis suppurativa (HS): systematic review and adjusted meta\u2010analysis"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5940-3555","authenticated-orcid":false,"given":"Kevin","family":"Phan","sequence":"first","affiliation":[{"name":"Department of Dermatology Liverpool Hospital Liverpool Sydney Australia"},{"name":"Faculty of Medicine University of New South Wales Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artiene","family":"Tatian","sequence":"additional","affiliation":[{"name":"Department of Dermatology Liverpool Hospital Liverpool Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Woods","sequence":"additional","affiliation":[{"name":"Department of Dermatology Liverpool Hospital Liverpool Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Cains","sequence":"additional","affiliation":[{"name":"Department of Dermatology Liverpool Hospital Liverpool Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5042-3632","authenticated-orcid":false,"given":"John W.","family":"Frew","sequence":"additional","affiliation":[{"name":"Department of Dermatology Liverpool Hospital Liverpool Sydney Australia"},{"name":"Faculty of Medicine University of New South Wales Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.06.020"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000363381"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00341181"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.04.003"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.11.040"},{"key":"e_1_2_6_7_1","unstructured":"PhanK TatianA RamachandranV WoodsJ CainsG FrewJ.The prevalence of inflammatory bowel disease (IBD) in hidradenitis suppurativa (HS) patients: a systematic review and meta\u2010analysis. 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