{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:51:56Z","timestamp":1791917516778,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T00:00:00Z","timestamp":1574899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Uremic pruritus is one of the most prevalent and bothersome dermatologic symptoms in patients with end\u2010stage renal disease. Some studies suggest a possible neuropathic cause of uremic pruritus. Gabapentin, an anticonvulsant, may control pruritus with neuropathic origin. The objectives of this study were to assess the efficacy of gabapentin in reducing pruritus scores of patients with uremic pruritus and evaluate its safety among dialysis patients. Meta\u2010analysis of randomized controlled trials, using gabapentin as treatment for uremic pruritus among hemodialysis patients was included and analyzed using Review Manager Version 5.1.4 software. Seven out of 17 screened articles were included, with a total of 315 participants. Meta\u2010analysis of the incidence of improved pruritus scores after treatment from four studies (<jats:italic>n<\/jats:italic>\u00a0=\u00a0171) showed that treatment with gabapentin decreased the severity of uremic pruritus as compared to the placebo (risk ratio\u00a0=\u00a00.18; 95% confidence interval: 0.09, 0.33; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a04%: <jats:italic>P<\/jats:italic>\u00a0=&lt;\u00a00.00001). Six studies (<jats:italic>n<\/jats:italic>\u00a0=\u00a0290) presented with incidence of adverse drug events such as dizziness, drowsiness, and somnolence. In the pooled analysis, treatment with gabapentin was associated with a higher incidence of adverse drug events compared to the comparator drugs, but the results were not significant (risk ratio\u00a0=\u00a01.3, 95% confidence interval: 0.81, 2.11; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.28, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a037%). The results of this systematic review suggest that gabapentin is efficacious and safe in improving uremic pruritus among dialysis patients.<\/jats:p>","DOI":"10.1111\/ijd.14708","type":"journal-article","created":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T09:24:54Z","timestamp":1574933094000},"page":"412-422","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Gabapentin for uremic pruritus: a systematic review of randomized controlled trials"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9856-7985","authenticated-orcid":false,"given":"Kathleen May V.","family":"Eusebio\u2010Alpapara","sequence":"first","affiliation":[{"name":"Section of Dermatology Department of Medicine University of the Philippines Philippine General Hospital Manila Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1704-9420","authenticated-orcid":false,"given":"Rochelle L.","family":"Castillo","sequence":"additional","affiliation":[{"name":"Section of Dermatology Department of Medicine University of the Philippines Philippine General Hospital Manila Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5494-9455","authenticated-orcid":false,"given":"Belen L.","family":"Dofitas","sequence":"additional","affiliation":[{"name":"Section of Dermatology Department of Medicine University of the Philippines Philippine General Hospital Manila Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.04249.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00100110"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.454"},{"key":"e_1_2_8_5_1","first-page":"86","article-title":"Gabapentin in the treatment of uremic itch: an index case and a pilot evaluation","volume":"18","author":"Manenti L","year":"2005","journal-title":"J Nephrol"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002757"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0007-0963.2004.05889.x"},{"key":"e_1_2_8_8_1","first-page":"1410","article-title":"Efficacy of gabapentin in the management of pruritus of unknown origin","volume":"5","author":"Hruza G","year":"2010","journal-title":"Clin J Am SocNephrol"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1L038"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1995.tb05020.x"},{"key":"e_1_2_8_11_1","unstructured":"HigginsJPT GreenS.Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration 2011. Available at:www.handbook.cochrane.org."},{"key":"e_1_2_8_12_1","first-page":"14","article-title":"Gabapentin for uremic pruritus in hemodialysis patients: a qualitative systematic review","volume":"28","author":"Lau T","year":"2016","journal-title":"Can J Kidney Health Dis"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2014.08.010"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2018010096"},{"key":"e_1_2_8_15_1","unstructured":"SiuYP.Hongkong: Hospital Authority. 2007 December 20-Identifier NCT00577967 Gabapentin-A Solution to Uremic Pruritus? A Prospective Randomized Placebo-controlled Double-blind Study;2010July. 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