{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:06:33Z","timestamp":1791655593957,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T00:00:00Z","timestamp":1574640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Paronychia is a common adverse event caused by epidermal growth factor receptor (EGFR) inhibitors. However, high rates of post\u2010treatment discomfort, infection, recurrence, and increased time to return to work have been noted after nail plate avulsion for EGFR inhibitor\u2010induced paronychia. Furthermore, poor wound healing and malnutrition were common conditions found in cancer patients. The aim of this study is to find an effective, pain\u2010relieving, and noninvasive treatment for patients with severe paronychia induced by EGFR inhibitors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from a series of 35 non\u2010small cell lung cancer cases suffering from EGFR inhibitor\u2010induced paronychia with pyogenic granuloma\u2010like lesions of digits treated with betaxolol 0.25% ophthalmic solution once daily were collected and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 35 patients suffering from grade 2 or 3 paronychia with pyogenic granuloma\u2010like lesions induced by EGFR inhibitors, 34 (97.1%) demonstrated complete resolution and only one (2.9%) had partial resolution after 12\u00a0weeks of topical betaxolol treatment. The grading of paronychia according to the Common Terminology Criteria for Adverse Events decreased from an average of 2.29 to 0.63 after 4\u00a0weeks of treatment (<jats:italic>P<\/jats:italic>\u00a0=\u00a05.55\u00a0\u00d7\u00a010<jats:sup>\u221216<\/jats:sup>). All the patients had significant improvement (50% pain reduction), as their pain visual analogue scale scores decreased from an average of 7.06 to 2.26 after one week of treatment (<jats:italic>P<\/jats:italic>\u00a0=\u00a06.11\u00a0\u00d7\u00a010<jats:sup>\u221225<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Betaxolol 0.25% ophthalmic solution is an effective, safe, and pain\u2010relieving treatment for patients suffering from EGFR inhibitor\u2010induced paronychia with pyogenic granuloma\u2010like lesions and deep fissures.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14730","type":"journal-article","created":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T10:45:06Z","timestamp":1574678706000},"page":"326-332","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Treatment of epidermal growth factor receptor inhibitor\u2010induced severe paronychia with pyogenic granuloma\u2010like lesions with topical betaxolol: an open\u2010label observation study"],"prefix":"10.1111","volume":"59","author":[{"given":"Chi\u2010Feng","family":"Yen","sequence":"first","affiliation":[{"name":"Department of Dermatology Drug Hypersensitivity Clinical and Research Center Chang Gung Memorial Hospital Taoyuan Taiwan"},{"name":"College of Medicine Chang Gung University Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao\u2010Kai","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan"},{"name":"International Research Center of Wound Repair and Regeneration (iWRR) National Cheng Kung University Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsing\u2010San","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaw\u2010Ning","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching\u2010Chi","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Drug Hypersensitivity Clinical and Research Center Chang Gung Memorial Hospital Taoyuan Taiwan"},{"name":"College of Medicine Chang Gung University Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Hung","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Dermatology Drug Hypersensitivity Clinical and Research Center Chang Gung Memorial Hospital Taoyuan Taiwan"},{"name":"College of Medicine Chang Gung University Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Liang","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Oncology and Interventional Bronchoscopy Department of Thoracic Medicine Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong\u2010Hwei Su","family":"Pang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medical Sciences Chang Gung University Taoyuan Taiwan"},{"name":"Department of Physical Medicine and Rehabilitation Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuang\u2010Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Drug Hypersensitivity Clinical and Research Center Chang Gung Memorial Hospital Taoyuan Taiwan"},{"name":"College of Medicine Chang Gung University Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Shien","family":"Ko","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Microscope Core Laboratory Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9341-4012","authenticated-orcid":false,"given":"Chun\u2010Wei","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Drug Hypersensitivity Clinical and Research Center Chang Gung Memorial Hospital Taoyuan Taiwan"},{"name":"College of Medicine Chang Gung University Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04791.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.10.009"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3747\/co.22.2430"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.09.050"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)71133-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.78.5.377"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12310.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2016-218589"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.2390"},{"key":"e_1_2_7_11_1","first-page":"924","article-title":"Topical 0.5% timolol heals a recalcitrant irradiated surgical scalp wound","volume":"40","author":"Beroukhim K","year":"2014","journal-title":"Dermatol Surg"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.08.005"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.01.015"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.12148"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2011.05082.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/08998280.2014.11929093"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.51"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2008.07.012"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007784109255"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00581.2007"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13071"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.4120"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12767"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1993.tb04661.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon.11.62"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.14730","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.14730","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijd.14730","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.14730","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T05:54:36Z","timestamp":1694152476000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.14730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,25]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1111\/ijd.14730"],"URL":"https:\/\/doi.org\/10.1111\/ijd.14730","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,25]]},"assertion":[{"value":"2019-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}