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Currently, there are no treatment guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To systematically assess the existing literature on various treatment modalities and their efficacies when used in the management of EPD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence review<\/jats:title><jats:p>We searched PubMed, Cochrane Libraries, Scopus, and <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clicnialtrial.gov\">clicnialtrial.gov<\/jats:ext-link> databases for articles in the English language with no limited time frame. Emphasis was placed on articles that reported on treatment for EPD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>Of the 168 articles identified by the literature search, 92 met eligibility criteria and were included for qualitative analysis. Efficacious topical treatments included clobetasol, betamethasone, and tacrolimus. Ninety\u2010three and 88% of cases utilizing clobetasol and betamethasone respectively demonstrated improvement or resolution. All 32 cases utilizing tacrolimus reported improvement. Efficacious systemic treatments included oral steroids such as prednisone, methylprednisolone, and dexamethasone. Topical dapsone, photodynamic therapy, systemic steroids, cyclosporine, and oral zinc derivatives were also described with some success.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and relevance<\/jats:title><jats:p>According to available data, limited solely to case reports and case series, potent topical steroids are an effective treatment option for EPD. Topical tacrolimus may also be considered in cases that require long\u2010term use or maintenance. Other treatment modalities shown to be successful based on high reported efficacy and low rates of recurrence after treatment include topical dapsone, systemic steroids, zinc derivatives, and cyclosporine. Further studies are needed to compare treatment modalities and to establish treatment protocols.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14744","type":"journal-article","created":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T12:10:03Z","timestamp":1578312603000},"page":"770-786","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Treatment of erosive pustular dermatosis: a systematic review of the literature"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1871-571X","authenticated-orcid":false,"given":"Katrina H.","family":"Lee","sequence":"first","affiliation":[{"name":"School of Medicine University of California, Irvine Irvine CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sama K.","family":"Carley","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California, Irvine Irvine CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina N.","family":"Kraus","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California, Irvine Irvine CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha A.","family":"Mesinkovska","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California, Irvine Irvine CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/ddg.13387","article-title":"Erosive pustular dermatosis of the scalp: reappraisal of an underrecognized entity","volume":"16","author":"Wilk M","year":"2018","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.10.029"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/828749"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2010.22.2.232"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000341528"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14539"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04878.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20132109"},{"key":"e_1_2_7_10_1","unstructured":"HowickJ ChalmersI LindJ et al.Oxford Centre for Evidence\u2010Based Medicine 2011 Levels of Evidence.http:\/\/www.cebm.net\/index.aspx?o=5653. 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