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To characterize existing literature on these reports, we queried the PubMed\/MEDLINE database for cases of SJS or TEN associated with checkpoint inhibitors. We identified 18 cases of SJS or TEN\u2010like reactions to checkpoint inhibitors in the literature. There were 12 cases of SJS\u2010like rashes with median time to onset of 5.6\u00a0weeks (average of 8.9\u00a0weeks), of which five were delayed to week 8 or later from checkpoint inhibitor initiation. The five TEN\u2010like reactions had a median time to onset of 4\u00a0weeks (average of 5.38\u00a0weeks), of which two were delayed to week 6 or later. SJS\/TEN\u2010like reactions to nivolumab (seven cases) had median onset time of 3\u00a0weeks, whereas five cases secondary to pembrolizumab had median onset time of 11\u00a0weeks. Seven cases in this study described prodromal rashes, which varied from localized papular rashes to generalized morbilliform rashes, prior to evolution into SJS or TEN\u2010like patterns. SJS\u2010like patterns generally improved well on systemic treatment\/supportive care and no cases of death were identified, but mortality occurred in three of five patients with TEN\u2010like reactions. Dermatologists should consider the possibility for unique features of SJS\/TEN in response to checkpoint inhibitors. Additional studies will be necessary to further characterize SJS\/TEN\u2010like eruptions on checkpoint inhibitors and determine the optimal management of these cases.<\/jats:p>","DOI":"10.1111\/ijd.14811","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T09:02:12Z","timestamp":1581584532000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Stevens\u2010Johnson syndrome and toxic epidermal necrolysis\u2010like reactions to checkpoint inhibitors: a systematic review"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9722-5673","authenticated-orcid":false,"given":"Nolan J.","family":"Maloney","sequence":"first","affiliation":[{"name":"Division of Dermatology Department of Medicine David Geffen School of Medicine at UCLA Los Angeles CA 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