{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:35:35Z","timestamp":1761514535173},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T00:00:00Z","timestamp":1581638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Voriconazole and genus beta human papillomavirus (HPV) are independently associated with the development of photo\u2010exposed cutaneous squamous cell carcinoma (SCC) but have not been evaluated concurrently. The objective of this study is to determine the prevalence and type of detectable HPV DNA in voriconazole\u2010associated SCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>SCCs from immunosuppressed patients, in those with and without voriconazole exposure, were evaluated by PCR analysis for HPV DNA and compared to SCC from non\u2010immunosuppressed patients. An additional expanded PCR analysis of all SCC that developed in the voriconazole group was also performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HPV DNA was detected by PCR in all groups regardless of the immunosuppression status (80.5%) with beta HPV most prevalent (64.3\u201378.6%). However, immunosuppressed patients were significantly more likely to be infected by beta HPV types 5, 8, 14, 20, and 21 (<jats:italic>P<\/jats:italic>\u2010value 0.014), and represented the majority of beta HPV types found in the voriconazole group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this retrospective study, beta HPV 5, 8, 14, 20, and 21 were commonly detected in voriconazole\u2010associated SCC. The results indicate a possible role of beta HPV in the pathogenesis of cutaneous SCC in photo\u2010exposed areas. Further studies are needed to establish the role of HPV and voriconazole in the pathogenesis of the lesion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14820","type":"journal-article","created":{"date-parts":[[2020,2,15]],"date-time":"2020-02-15T07:24:42Z","timestamp":1581751482000},"page":"595-598","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Presence of human papillomavirus DNA in voriconazole\u2010associated cutaneous squamous cell carcinoma"],"prefix":"10.1111","volume":"59","author":[{"given":"Cuong V.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Dermatology Northwestern University Feinberg School of Medicine Chicago IL USA"},{"name":"Department of Dermatology Perelman School of Medicine at the University of Pennsylvania Philadelphia PA 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USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Rubin","sequence":"additional","affiliation":[{"name":"Biostatistics Core Masonic Cancer Center University of Minnesota Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carrie L.","family":"Kovarik","sequence":"additional","affiliation":[{"name":"Department of Dermatology Perelman School of Medicine at the University of Pennsylvania Philadelphia PA 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