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The disease primarily affects the skin and soft tissue. As the state of deficiency persists, hematological and immunological sequelae may develop. The classic signs of scurvy are not always present and can be altered by the presence of other comorbidities. In this article, we present a challenging case of scurvy in an older male from an urban tertiary healthcare setting. We review the atypical and uncommon clinical and pathological findings of scurvy including those seen in the skin, blood, and bone marrow. We also review contemporary research findings that provide a better understanding of the pathogenicity and clinical manifestations of vitamin C deficiency.<\/jats:p>","DOI":"10.1111\/ijd.14832","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T09:11:04Z","timestamp":1583831464000},"page":"1450-1457","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Revisiting the pathobiology of scurvy: a review of the literature in the context of a challenging case"],"prefix":"10.1111","volume":"59","author":[{"given":"Hany","family":"Deirawan","sequence":"first","affiliation":[{"name":"Departments of Dermatology and Pathology Wayne State University School of Medicine Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph W.","family":"Fakhoury","sequence":"additional","affiliation":[{"name":"Departments of Dermatology and Pathology Wayne State University 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