{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T23:33:10Z","timestamp":1772753590462,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T00:00:00Z","timestamp":1585785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The management of nail psoriasis is an arduous task owing to the disease manifestations and anatomical structure of the nail plate. Although various treatment therapies are available for nail psoriasis, topical therapy is contemplated as one of the most favorable options as systemic therapies are accompanied by numerous side effects that result in patient incompliance. The topical formulations including creams, gels, ointments, and nail lacquers have been used as delivery systems for various antipsoriatic drugs. Among these, nail lacquers emerge to be promising and patient friendly formulations. However, the major defiance with topical delivery is inefficacious penetration of drug through impenetrable keratinized nail plate to reach the target sites: nail matrix and nail bed. Therefore, in order to obtain effectual drug delivery systems that can retain\/remain on the nail plate for a prolonged period of time and deliver the drug across it, systematic approaches like quality by design (QbD) need to be followed so that the desired quality can be \u201cbuilt in\u201d the system rather than to rely solely on retrograde evaluation. Furthermore, more advances in research are still required to develop a validated animal model so as to determine the efficacy of the formulation and to establish a mathematical model that can help in predicting the desirable attributes of the formulation and permeation of various molecules through the nail plate.<\/jats:p>","DOI":"10.1111\/ijd.14840","type":"journal-article","created":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T10:50:48Z","timestamp":1585824648000},"page":"915-925","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Management of nail psoriasis by topical drug delivery: a pharmaceutical perspective"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5066-4855","authenticated-orcid":false,"given":"Purva","family":"Thatai","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics Krupanidhi College of Pharmacy Bangalore Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arshad B.","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics Krupanidhi College of Pharmacy Bangalore Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.08.015"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.07.073"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000316169"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2165\/11597000-000000000-00000"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2007.01405.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0190-9622(03)00910-1"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03364.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03344.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12664"},{"key":"e_1_2_7_11_1","unstructured":"RobertsMS CrossSE PellettMA et al.Skin Transport.New York:Marcel Dekker 2002:89\u2013196."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.04.003"},{"key":"e_1_2_7_13_1","unstructured":"2013 Taylor and Francis Group Boca Raton S Murdan The nail: anatomy physiology diseases and treatment 1 36"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12142"},{"key":"e_1_2_7_15_1","first-page":"CD007633","article-title":"Interventions for nail psoriasis","author":"Vries AC","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.01.072"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-012-9411-0"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/10717544.2013.879355"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/03639045.2013.828219"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12230"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02462.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1998.tb02386.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000018281"},{"key":"e_1_2_7_24_1","first-page":"355","article-title":"Tazarotene 0.1% gel in the treatment of fingernail psoriasis: a double\u2010blind, randomized, vehicle\u2010controlled study","volume":"68","author":"Scher RK","year":"2001","journal-title":"Cutis"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/120347540400800208"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.5070\/D31T20Z9WW"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0195"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000202179"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2012.04.008"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04642.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.174389"},{"key":"e_1_2_7_32_1","first-page":"87","article-title":"A clinical evaluation of a new hydroxypropyl\u2010chitosan based nail lacquer in subjects with nail alterations at risk of onychomycosis","volume":"10","author":"Iorizzo M","year":"2014","journal-title":"J Plastic Dermatol"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04842-14"},{"key":"e_1_2_7_34_1","first-page":"1013","article-title":"Effects of a novel nail lacquer based on hydroxypropyl\u2010chitosan (HPCH) in subjects with fingernail onychoschizia","volume":"2","author":"Sparavigna A","year":"2014","journal-title":"J Dermatolog Clin Res"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03209.x"},{"key":"e_1_2_7_36_1","first-page":"185","article-title":"Randomized controlled trial of a water\u2010soluble nail lacquer based on hydroxypropyl\u2010chitosan (HPCH), in the management of nail psoriasis","volume":"7","author":"Cantoresi F","year":"2014","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"e_1_2_7_37_1","unstructured":"Nail Polish (Nail Enamel) \u2010 Specifications.Bureau of Indian Standards IS 9245:1994 (R2016)."},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.02679.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962012000200003"},{"key":"e_1_2_7_40_1","first-page":"1","article-title":"Treatment of nail psoriasis with combination of topical tazarotene and urea\u2010containing nail lacquer: preliminary experience on 6 patients","volume":"3","author":"Piraccini BM","year":"2015","journal-title":"Clin Dermatol"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-017-0776-3"},{"key":"e_1_2_7_42_1","unstructured":"BornM CremerT.Nail polish for the treatment of psoriasis.2007; KR100610517B1."},{"key":"e_1_2_7_43_1","unstructured":"DelaunoisM LefrancoisP NavarroR.Nail varnish containing tazarotene and its use in the treatment and\/or prevention of psoriasis.2007; ES2271373T3."},{"key":"e_1_2_7_44_1","unstructured":"ZhangJ WarnerKS KumarP et al.Systems methods and formulations for topically treating nail fungal infections and nail psoriasis.2009; US20090175945A1."},{"key":"e_1_2_7_45_1","unstructured":"ChesnoyS DelaunoisM CoubeterguesH et al.Urea\u2010based film\u2010forming solution for treating nail psoriasis.2015; EP2349243B1."},{"key":"e_1_2_7_46_1","first-page":"9","article-title":"Quality by design approaches for topical dermatological dosage forms","volume":"4","author":"Sivaraman A","year":"2015","journal-title":"Res Rep Transdermal Drug Deliv"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/348095"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v22.i1.20"},{"key":"e_1_2_7_49_1","first-page":"70","article-title":"Developing \u201coptimized\u201d drug products employing \u201cdesigned\u201d experiments","volume":"12","author":"Raza K","year":"2013","journal-title":"Chem Ind Dig"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2014.11.050"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.14840","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.14840","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijd.14840","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.14840","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T21:07:47Z","timestamp":1693948067000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.14840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,2]]},"references-count":49,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1111\/ijd.14840"],"URL":"https:\/\/doi.org\/10.1111\/ijd.14840","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,2]]},"assertion":[{"value":"2019-09-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}