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Integrins also play a prominent role in tumor growth and metastasis. Translational research has tried to define the contribution of integrins to the phenotypic aggressiveness of melanoma because such knowledge is clinically useful. For example, differential expression of integrins in primary cutaneous melanoma can be used to distinguish indolent from aggressive, prometastatic melanoma. Recent studies have shown that gene expression\u2013based testing of patient\u2010derived melanoma tissue is feasible, and molecular tests may fully replace interventional surgical methods such as sentinel lymph node biopsies in the future. Because of their central role in mediating invasion and metastasis, integrins are likely to be useful biomarkers. Integrins are also attractive candidate targets for interventional therapy. This article focuses on the role of integrins in melanoma and highlights recent advances in the field of translational research.<\/jats:p>","DOI":"10.1111\/ijd.14850","type":"journal-article","created":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T00:50:17Z","timestamp":1583887817000},"page":"525-534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["The role of integrins in melanoma: a review"],"prefix":"10.1111","volume":"59","author":[{"given":"Suzette M.","family":"Arias\u2010Mejias","sequence":"first","affiliation":[{"name":"Department of Dermatology Mayo Clinic Rochester MN USA"},{"name":"Center for Clinical and Translational Sciences Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina Y.","family":"Warda","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic Rochester MN 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