{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T03:44:42Z","timestamp":1781840682684,"version":"3.54.5"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T00:00:00Z","timestamp":1586995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>External anogenital warts are proliferative lesions. Till now, there is no consensus on the standard treatment of external anogenital warts. The combination of ablative therapy and self\u2010administered treatment has been reported to achieve sustained complete clearance than ablative therapy. The aim of this review was to compare the efficacy on achieving complete clearance of warts between the combination of ablative therapy with self\u2010administered therapy and ablative therapy alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a systematic review to evaluate the efficacy and safety of the combination of ablative therapy and self\u2010administered treatment for external anogenital warts. The Cochrane Central Register of Controlled Trials, Medline, Embase and Science Citation Index Expanded, China National Knowledge Infrastructure and Wanfang were searched.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 1138 initially identified publications, 37 studies in English and Chinese were included. The combination of ablative therapy and self\u2010administered treatment therapy showed significantly high complete clearance rates at 4, 8, 12, or 24\u00a0weeks after treatment\u00a0compared to ablative therapy alone. In a subgroup analysis based on the treatment duration of imiquimod cream therapy, 4 and 8\u00a0weeks of imiquimod 5% cream plus CO<jats:sub>2<\/jats:sub> laser produced similar efficacy on clearance. The combination therapy is tolerable for patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In conclusion, this review provided evidence to support the use of the combination of ablative therapy and self\u2010administered treatment for external anogenital warts to maintain sustained clearance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14863","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T13:45:53Z","timestamp":1587044753000},"page":"1210-1216","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A systematic review evaluating the efficacy and safety of a\u00a0combination of ablative treatment and self administered treatment versus ablative treatment alone for external anogenital warts"],"prefix":"10.1111","volume":"59","author":[{"given":"Cheng","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Cancer Center Beijing Ditan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loubin","family":"Si","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixiong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/590560"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-39"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2017-053150"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04493.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956462417711622"},{"key":"e_1_2_6_7_1","first-page":"25","article-title":"Genital warts: a comprehensive review","volume":"5","author":"Yanofsky VR","year":"2012","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1177\/0956462418797874","article-title":"Efficacy of sinecatechins 10% as proactive sequential therapy of external genital warts after laser CO2 ablative therapy: the PACT study (post\u2010ablation immunomodulator treatment of condylomata with sinecatechins): a randomized, masked outcome assessment, multicenter trial","volume":"30","author":"Puviani M","year":"2018","journal-title":"Int J STD AIDS"},{"key":"e_1_2_6_9_1","first-page":"1400","article-title":"A single\u2010blinded randomized controlled study to assess the efficacy of twice daily application of sinecatechins 15% ointment when used sequentially with cryotherapy in the treatment of external genital warts","volume":"13","author":"On SC","year":"2014","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.07.003"},{"key":"e_1_2_6_11_1","first-page":"CD010389","article-title":"Imiquimod for anogenital warts in non\u2010immunocompromised adults","volume":"11","author":"Grillo\u2010Ardila CF","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-018-0375-4"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13789"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta20240"},{"key":"e_1_2_6_15_1","unstructured":"HigginsJPT GreenS.Cochrane Handbook for Systematic Reviews of Interventions. 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