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EBV can cause asymptomatic infection, nonspecific symptoms or, especially in adolescents and young adults, the infectious mononucleosis (IM), characterized by pharyngitis, lymphadenopathy, fatigue, and fever. Two main types of skin rashes, accounted as atypical exanthems, occur in patients with acute IM: a faint erythematous maculopapular eruption of 24\u201348\u00a0hours duration (5\u201315% of the patients) or a pruritic maculopapular rash in almost all patients receiving ampicillin or amoxicillin. Moreover EBV acute infection has been related to other cutaneous manifestations, such as Gianotti\u2010Crosti syndrome, unilateral laterothoracic exanthem (especially in children), and others. In this study, we reported a case of atypical exanthem with an erythematous\u2010papulovesicular pattern in a 22\u2010year\u2010old female patient with IM and performed a review of the literature of the cutaneous and mucosal eruptions occurring during EBV acute infections.<\/jats:p>","DOI":"10.1111\/ijd.14887","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T06:51:00Z","timestamp":1588143060000},"page":"1202-1209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Dermatological manifestations of Epstein\u2010Barr virus systemic infection: a case report and literature review"],"prefix":"10.1111","volume":"59","author":[{"given":"Giulia","family":"Ciccarese","sequence":"first","affiliation":[{"name":"Dermatology Clinic Ospedale Policlinico San Martino Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5469-4517","authenticated-orcid":false,"given":"Ilaria","family":"Trave","sequence":"additional","affiliation":[{"name":"DI.S.Sal. 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