{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T06:21:00Z","timestamp":1774333260826,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,5,2]],"date-time":"2020-05-02T00:00:00Z","timestamp":1588377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Leprosy can cause acute reactions, which may be type 1 (reverse reaction) or type 2 (erythema nodosum leprosum \u2013 ENL). ENL has been classified as mild, moderate, or severe. In order to standardize the classification, the Erythema Nodosum Leprosum International Study (ENLIST) Group has developed an objective scale, the ENLIST ENL Severity Scale (EESS), which was the first validated severity scale of ENL in the world. The goal of the study was\u00a0to describe the sociodemographic and clinical characteristics of patients with ENL attending a tertiary hospital in Piau\u00ed, Brazil, classifying them according to the EESS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A descriptive cross\u2010sectional observational study was conducted on 26 patients recruited sequentially from May 2017 to February 2018. Their data were statistically analyzed and compared against each other through a structured questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>According to the score obtained in the scale, the patients were divided into two groups: mild ENL and moderate\/severe ENL. The extent and number of nodules were related to the severity of the cases, and these data were statistically significant. The majority of the patients were male, between the ages of 31 and 49\u00a0years old, with low educational level, and residents in the urban area.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This was the first study to use EESS in Brazil. This scale is easy to apply and allows for the enhancement of treatment protocols. The study also showed a correlation between the number and extension of nodules and the severity of the condition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14895","type":"journal-article","created":{"date-parts":[[2020,5,2]],"date-time":"2020-05-02T11:28:36Z","timestamp":1588418916000},"page":"856-861","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Epidemiological profile and severity of erythema nodosum leprosum in Brazil: a cross\u2010sectional study"],"prefix":"10.1111","volume":"59","author":[{"given":"Caroline","family":"Baima de Melo","sequence":"first","affiliation":[{"name":"Federal University of Piaui Teresina Piaui Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e1rbara D.","family":"Silva de S\u00e1","sequence":"additional","affiliation":[{"name":"Uninovafapi University Centre Teresina Piaui Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filipe","family":"An\u00edbal Carvalho Costa","sequence":"additional","affiliation":[{"name":"Oswaldo Cruz Foundation Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Euzenir","family":"Nunes Sarno","sequence":"additional","affiliation":[{"name":"Oswaldo Cruz Foundation Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005716"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004065"},{"key":"e_1_2_5_4_1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.47276\/lr.79.3.254","article-title":"Erythema nodosum leprosum in Nepal: a retrospective study of clinical features and response to treatment with prednisolone or thalidomide","volume":"79","author":"Feuth M","year":"2008","journal-title":"Lepr Rev"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006011"},{"key":"e_1_2_5_6_1","first-page":"389","article-title":"Erythema nodosum leprosum: clinical and therapeutic up\u2010date","volume":"77","author":"Guerra JG","year":"2002","journal-title":"An Bras Dermatol"},{"key":"e_1_2_5_7_1","first-page":"99","article-title":"Reacciones por lepra en un centro de referencia nacional en Colombia","volume":"33","author":"Nova J","year":"2013","journal-title":"Biom\u00e9dica"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.5341"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005364"},{"key":"e_1_2_5_10_1","first-page":"011","article-title":"Caracteriza\u00e7\u00e3o da situa\u00e7\u00e3o epidemiol\u00f3gica da hansen\u00edase e diferen\u00e7as por sexo, Brasil, 2012\u20132016","volume":"49","author":"Minist\u00e9rio da Sa\u00fade (BR). Secretaria de Vigil\u00e2ncia em Sa\u00fade","year":"2018","journal-title":"Bol Epidemiol"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86822004000500003"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyl072"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2006.74.868"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.14895","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijd.14895","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.14895","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T03:14:27Z","timestamp":1693970067000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.14895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,2]]},"references-count":12,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1111\/ijd.14895"],"URL":"https:\/\/doi.org\/10.1111\/ijd.14895","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,2]]},"assertion":[{"value":"2019-04-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}