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This study aims to describe dermatologic complications in breast cancer patients during chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This longitudinal prospective observational study included data on women with non\u2010metastatic breast cancer whom were treated with AC\u2010T protocol (anthracycline, cyclophosphamide, and taxane) adjuvant chemotherapy and consecutively enrolled during two years. The study was performed in an educational and tertiary referral center. The patients\u2019 information including age, body mass index (BMI), past medical history, and different dermatologic complications were collected for all participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 190 enrolled women, all patients experienced alopecia, which occurred in 131 patients (68.9%) after the first cycle. Skin, mucosal, and nail involvement were respectively seen in 46 (24.2%), 51 (26.8%), and 86 (45.2%) cases. Cutaneous complications were observed mainly between the\u00a0third and sixth chemotherapy cycles. Palmoplantar erythema and palmoplantar dysesthesia were the most common cutaneous complications. Dermatologic adverse effects were significantly more frequent in the patients with an underlying disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings suggest that dermatologic adverse effects of adjuvant chemotherapy are common and could be induced by all components of AC\u2010T regimen. These complications should be skillfully managed to increase patients\u2019 comfort.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14916","type":"journal-article","created":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T00:53:16Z","timestamp":1589417596000},"page":"822-828","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Dermatologic adverse effects of breast cancer chemotherapy: a longitudinal prospective observational study with a review of literature"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0850-488X","authenticated-orcid":false,"given":"Narges","family":"Alizadeh","sequence":"first","affiliation":[{"name":"Skin Research Center Department of Dermatology School of Medicine Razi Hospital Guilan University of Medical Sciences Rasht Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyyed Hossein","family":"Mirpour","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology School of Medicine Razi Hospital Guilan University of Medical Sciences Rasht Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7860-5232","authenticated-orcid":false,"given":"Abbas","family":"Darjani","sequence":"additional","affiliation":[{"name":"Skin Research Center Department of Dermatology School of Medicine Razi Hospital Guilan University of Medical Sciences Rasht Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6599-0058","authenticated-orcid":false,"given":"Rana","family":"Rafiei","sequence":"additional","affiliation":[{"name":"Skin Research Center Department of Dermatology School of Medicine Razi Hospital Guilan University of Medical Sciences Rasht Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elahe","family":"Rafiei","sequence":"additional","affiliation":[{"name":"Razi Clinical Research Development Unit Guilan University of Medical Sciences Rasht Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Mohammadhoseini","sequence":"additional","affiliation":[{"name":"Skin Research Center Department of Dermatology School of Medicine Razi Hospital Guilan University of Medical Sciences Rasht Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4741.2007.00446.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S40601"},{"key":"e_1_2_7_4_1","first-page":"203\u2013","article-title":"Cutaneous reactions to chemotherapeutic drugs and targeted therapies for cancer: part I. 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