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Herein we review Gleich syndrome and assess clinical features, epidemiology, and treatment options. Thirty\u2010two articles including case reports or case series of eosinophilic angioedema and Gleich syndrome were included. Data regarding patient age, gender, and history, clinical and biological manifestations, and treatment protocols were recorded. The most common clinical findings include recurrent or non\u2010recurrent angioedema, fever, urticaria, weight gain, blood eosinophilia, and elevated immunoglobulin levels. Corticosteroid therapy is the mainstay of treatment. Gleich syndrome is a distinctive hypereosinophilic entity with a benign course and good response to systemic corticosteroids. More studies are needed to evaluate the pathophysiology of this syndrome and lead to better therapeutic options.<\/jats:p>","DOI":"10.1111\/ijd.14963","type":"journal-article","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T12:51:04Z","timestamp":1592484664000},"page":"1458-1465","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Gleich syndrome: a systematic review"],"prefix":"10.1111","volume":"59","author":[{"given":"Roger","family":"Haber","sequence":"first","affiliation":[{"name":"Dermatology Department Faculty of Medicine Balamand University Saint Georges Hospital UMC Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna A.","family":"Chebl","sequence":"additional","affiliation":[{"name":"Pulmonary Medicine and Critical Care Department Saint Georges Hospital UMC Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"El Gemayel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Faculty of Medicine Hotel\u2010Dieu de France UMC Saint Joseph University Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7184-9859","authenticated-orcid":false,"given":"Antoine","family":"Salloum","sequence":"additional","affiliation":[{"name":"Dermatology Department Faculty of Medicine Balamand University Saint Georges Hospital UMC Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2015.10.288"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198406213102501"},{"key":"e_1_2_11_4_1","first-page":"401","article-title":"Cyclical hypereosinophilia with skin manifestations and a clonal T cell population","volume":"18","author":"Gonz\u00e1lez 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