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Herein, we attempt to identify potentially safe immunotherapies that may be used in the treatment of cutaneous diseases during the current COVID\u201019 pandemic. We performed a literature review to approximate the risk of SARS\u2010CoV\u20102 infection, including available data on the roles of relevant cytokines, cell subsets, and their mediators in eliciting an optimal immune response against respiratory viruses in murine gene deletion models and humans with congenital deficiencies were reviewed for viral infections risk and if possible coronaviruses specifically. Furthermore, reported risk of infections of biologic and non\u2010biologic therapeutics for skin diseases from clinical trials and drug data registries were evaluated. Many of the immunotherapies used in dermatology have data to support their safe use during the COVID\u201019 pandemic including the biologics that target IgE, IL\u20104\/13, TNF\u2010\u03b1, IL\u201017, IL\u201012, and IL\u201023. Furthermore, we provide evidence to show that oral immunosuppressive medications such as methotrexate and cyclosporine do not significantly increase the risk to patients. Most biologic and conventional immunotherapies, based on doses and indications in dermatology, do not appear to increase risk of viral susceptibility and are most likely safe for use during the COVID\u201019 pandemic. The limitation of this study is availability of data on COVID\u201019.<\/jats:p>","DOI":"10.1111\/ijd.15028","type":"journal-article","created":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T06:28:53Z","timestamp":1593844133000},"page":"1043-1056","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Infection risk of dermatologic therapeutics during the COVID\u201019 pandemic: an evidence\u2010based recalibration"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5848-128X","authenticated-orcid":false,"given":"Feras M.","family":"Ghazawi","sequence":"first","affiliation":[{"name":"Division of Dermatology University of Ottawa Ottawa ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1548-4357","authenticated-orcid":false,"given":"Megan","family":"Lim","sequence":"additional","affiliation":[{"name":"Division of Dermatology University of Ottawa Ottawa ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3035-0522","authenticated-orcid":false,"given":"Jan P.","family":"Dutz","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Skin Sciences University of British Columbia Vancouver BC Canada"},{"name":"BC Children's Hospital Research Institute Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4015-8377","authenticated-orcid":false,"given":"Mark G.","family":"Kirchhof","sequence":"additional","affiliation":[{"name":"Division of Dermatology University of Ottawa Ottawa ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,3]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2020.105924"},{"key":"e_1_2_4_3_1","first-page":"e13298","article-title":"Zalaudek. 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