{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T03:44:40Z","timestamp":1786592680019,"version":"build-2736575974"},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T00:00:00Z","timestamp":1595203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Toxic epidermal necrolysis (TEN) is a life\u2010threatening severe cutaneous adverse reaction. Data on pediatric TEN is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Case records of 44 children, 1\u00a0month\u201312\u00a0years with a diagnosis of TEN (&gt;30% body surface area [%BSA] detachment) admitted to a tertiary pediatric intensive care unit (PICU) between 2009 and 2018 were analyzed retrospectively. The primary outcome was mortality, and secondary outcomes were organ dysfunction, length of stay (LOS), and long\u2010term sequelae.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median (IQR) age was 6.5 (3.6, 8.0)\u00a0years, and 25 (57%) were boys. Median (IQR) %BSA involved, SCORTEN score, and PRISM\u2010III were 65% (45, 80); 2 (2, 3) and 13 (10, 16), respectively. Antiepileptics (<jats:italic>n<\/jats:italic>\u00a0=\u00a024, 54.6%) and antimicrobials (<jats:italic>n<\/jats:italic>\u00a0=\u00a08, 18.2%) were the most common offending agents. Twenty\u2010four (54.5%) children had culture positive sepsis. Immunomodulatory therapy was provided in 35 (79.5%) and conservative management in nine (20.5%) children. Intravenous immunoglobulin (IVIG) was given in 22 (50%), steroids in three (6.8%), and both IVIG and steroids in 10 (22.7%) children. Respiratory failure (<jats:italic>n<\/jats:italic>\u00a0=\u00a014, 31.8%) was the commonest organ failure. Mortality was 15.9% (<jats:italic>n<\/jats:italic>\u00a0=\u00a07), and median (IQR) PICU\u2010LOS in survivors was 8 (4, 11.75)\u00a0days. There was no association between IVIG, steroids, or conservative management with mortality or LOS. Ocular sequelae (<jats:italic>n<\/jats:italic>\u00a0=\u00a020, 54.1%) were the most common long\u2010term complication followed by skin (18, 40.1%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Immunomodulation with IVIG or steroids was not associated with any mortality benefit as compared to conservative management alone. Further research is required to determine the most effective treatment in pediatric TEN.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.15054","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T07:04:28Z","timestamp":1595228668000},"page":"44-52","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Intensive care needs and long\u2010term outcome of pediatric toxic epidermal necrolysis \u2013 A 10\u2010year experience"],"prefix":"10.1111","volume":"60","author":[{"given":"Vijai","family":"Williams","sequence":"first","affiliation":[{"name":"Division of Pediatric Critical Care Department of Pediatrics Advanced Pediatrics Centre Postgraduate Institute of Medical Education and Research (PGIMER) Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mounika","family":"Reddy","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care 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