{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T21:02:24Z","timestamp":1770325344136,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T00:00:00Z","timestamp":1595980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Amelanotic and hypomelanotic melanoma (AHM) has a higher risk of delayed diagnosis and a significant lower 5\u2010year melanoma\u2010specific survival compared to pigmented melanoma. Our aim was the evaluation of the clinicopathological\/dermoscopic features of amelanotic melanoma (AM) and hypomelanotic melanoma (HM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All participants had a personal history of AHM. We defined HM as showing clinical\/dermoscopic pigmentation in\u00a0&lt;\u00a025% of the lesion\u2019s surface and histopathological focal pigmentation, while AM as melanomas with clinical\/dermoscopic and histopathological absence of pigmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The most common phenotypic traits among the 145 AHM patients were as follows: phototype II, blue\u2010grey eyes, and dark brown hair. Red hair was present in 23.8% AHM cases (AM\u00a0=\u00a022.60%; HM\u00a0=\u00a025.80%). The most affected area was the back (29.5%). A total of 67.1% were classified as AM and 32.9% as HM. The most represented hair colors in AM and HM were, respectively, blonde and dark brown hair. Median Breslow thickness was 1.7 mm, superficial spreading melanoma (SSM) and nodular melanoma (NM) were the most represented histotypes, and mitotic rate &gt;\u00a01\u00a0\u00d7\u00a0mm<jats:sup>2<\/jats:sup>was reported in 73.3% cases, and regression was significantly more present in HM. Dermoscopy showed high prevalence of white structureless zones (63.4%), linear looped vessels (58.8%), linear irregular vessels (50.0%), and arborizing vessels (47.2%). Multivariate logistic regression confirmed the association between the presence of pigmentation and the following: histological regression, dermoscopic globules, and arborizing vessels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Predominance of red hair in AHM patients was not confirmed. AHM affects mostly intermittent sun\u2010exposed body areas. The deeper median Breslow thickness (versus pigmented melanoma), the association of AM with the nodular histotype, and the high mitotic rate highlight the AHM\u2019s aggressiveness. HM\u2019s higher levels of regression can be explained by the presence of pigmentation, driving the underlying immune response. AHM showed a polymorphous vascular pattern and significant presence of arborizing vessels (especially HM).<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.15064","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T18:33:22Z","timestamp":1596047602000},"page":"1371-1380","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Clinicopathological and dermoscopic features of amelanotic and hypomelanotic melanoma: a retrospective multicentric study"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3032-2217","authenticated-orcid":false,"given":"Giovanni","family":"Paolino","sequence":"first","affiliation":[{"name":"Unit of Dermatology IRCCS Ospedale San Raffaele Milan Italy"},{"name":"Dermatologic Clinic La Sapienza University of Rome Rome 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Sanitaria Locale \u2010 IRCCS di Reggio Emilia Reggio Emilia Italy"},{"name":"Department of Dermatology University of Modena and Reggio Emilia Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5592-8485","authenticated-orcid":false,"given":"Pasquale","family":"Frascione","sequence":"additional","affiliation":[{"name":"Oncologic and Preventative Dermatology San Gallicano Dermatological Institute IRCCS Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Department of Pathology IRCCS Ospedale San Raffaele Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margherita","family":"Raucci","sequence":"additional","affiliation":[{"name":"Dermatologic Clinic La Sapienza University of Rome Rome 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