{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:05:43Z","timestamp":1791655543755,"version":"4.3.4"},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CIRPD1D0032"],"award-info":[{"award-number":["CIRPD1D0032"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPGBI0011\u20103"],"award-info":[{"award-number":["CMRPGBI0011\u20103"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NMRPD1G1171"],"award-info":[{"award-number":["NMRPD1G1171"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NMRPD1H1031"],"award-info":[{"award-number":["NMRPD1H1031"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>High rates of posttreatment discomfort, infection, recurrence, and increased time to return to work have been noted after nail plate avulsion resulting from epidermal growth factor receptor tyrosine kinase inhibitor(EGFR\u2010TKI)\u2010induced paronychia, which may even interrupt the course of treatment for EGFR\u2010TKI therapy. Thus, we conducted this study to determine how effectively a topical \u03b2\u2010blocker, betaxolol, prevents EGFR\u2010TKI\u2010induced paronychia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This case\u2013control cohort study included a total of 131 non\u2010small\u2010cell lung cancer patients. The prevention group comprised 40 patients treated with topical betaxolol 0.25% solution to prevent paronychia while they received EGFR\u2010TKI therapy. The control group comprised 91 patients who did not preventively use topical betaxolol 0.25% solution while receiving EGFR\u2010TKI therapy. The patients\u2019 age, gender, antineoplastic regimen, duration of antineoplastic treatment before the appearance of lesions, number of involved digits (fingernails or toenails) with lesions, grading of paronychia, and pain score were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In terms of the cumulative incidence of paronychia, significant differences (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) were noted at both the 2nd and 3rd months after starting EGFR\u2010TKIs. Furthermore, the average visual analogue scale scores were 3.125 and 6.29 in the prevention group and control group, respectively (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). The average grades of paronychia were 1.5 and 2.12 in the prevention group and control group, respectively (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). The average numbers of involved digits were 2.25 (range: 1\u20135 digits) in the prevention group and 3.03 (range: 1\u20137) in the control group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.07).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Preventively using topical betaxolol can significantly decrease the incidence, VAS score, and grading of EGFR\u2010TKI\u2010induced paronychia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.15099","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T10:21:27Z","timestamp":1601029287000},"page":"179-184","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Using betaxolol for the prevention of paronychia induced by epidermal growth factor receptor inhibitors: a case\u2013control cohort study"],"prefix":"10.1111","volume":"60","author":[{"given":"Chun\u2010Wei","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Dermatology Drug Hypersensitivity Clinical and Research Center Chang Gung Memorial Hospital Taoyuan Taiwan"},{"name":"College of Medicine Chang Gung University Taoyuan Taiwan"},{"name":"Graduate Institute of Clinical Medical Sciences Chang Gung University Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting\u2010Ya","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Feng","family":"Yen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Drug Hypersensitivity Clinical and Research Center Chang Gung Memorial Hospital Taoyuan Taiwan"},{"name":"College of Medicine Chang Gung University Taoyuan 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Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping\u2010Chih","family":"Hsu","sequence":"additional","affiliation":[{"name":"College of Medicine Chang Gung University Taoyuan Taiwan"},{"name":"Division of Thoracic Medicine Department of Internal Medicine Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueh\u2010Fu","family":"Fang","sequence":"additional","affiliation":[{"name":"College of Medicine Chang Gung University Taoyuan Taiwan"},{"name":"Division of Thoracic Medicine Department of Internal Medicine Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Hong","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Thoracic Medicine Department of Internal Medicine Chang Gung Memorial Hospital Taoyuan 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