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This review aimed to explore and summarize available cases of SJS\/TEN suspected to be associated with the use of macrolide antibiotics reported in the literature. Electronic searches were conducted in PubMed\/MEDLINE, Web of Science, Scopus, and Serbian Citation Index (SCIndeks). Twenty\u2010five publications describing a total of 27 patients were included. Cases of SJS\/TEN which satisfied inclusion criteria were found for azithromycin (<jats:italic>n<\/jats:italic>\u00a0=\u00a011), clarithromycin (<jats:italic>n<\/jats:italic>\u00a0=\u00a07), erythromycin (<jats:italic>n<\/jats:italic>\u00a0=\u00a05), roxithromycin (<jats:italic>n<\/jats:italic>\u00a0=\u00a02), and telithromycin (<jats:italic>n<\/jats:italic>\u00a0=\u00a02). The age of the patients ranged from 2 to 77\u00a0years (median: 29\u00a0years). There were 14 female (51.9%) and 13 male (48.1%) patients. SJS was diagnosed in 16 patients (59.3%), TEN in 10 patients (37.0%), and SJS\/TEN overlap in one patient (3.7%). Time to onset of the first symptoms ranged from 1 to 14\u00a0days (median: 3\u00a0days). All patients received some form of supportive and symptomatic care. Systemic corticosteroids were reported to be administered in 12 patients (44.4%) and intravenous immunoglobulin in five patients (18.5%). Three patients (11.1%) died. Considering that SJS\/TEN is a severe and potentially life\u2010threatening reaction, physicians should be aware that they could be adverse effects of macrolide antibiotics and keep in mind that prompt recognition of SJS\/TEN and discontinuation of the culprit drug in combination with supportive care is essential.<\/jats:p>","DOI":"10.1111\/ijd.15144","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T20:39:27Z","timestamp":1598474367000},"page":"12-24","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Stevens\u2010Johnson syndrome and toxic epidermal necrolysis associated with the use of macrolide antibiotics: a review of published cases"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1741-0025","authenticated-orcid":false,"given":"Ana V.","family":"Pej\u010di\u0107","sequence":"first","affiliation":[{"name":"Department of Pharmacology and 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