{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:30:31Z","timestamp":1765758631419,"version":"3.40.5"},"reference-count":74,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T00:00:00Z","timestamp":1600214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Besides predominant respiratory and gastrointestinal manifestations, reports on cutaneous manifestations in COVID\u201019 patients are being noted increasingly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To estimate the prevalence of cutaneous manifestations in COVID\u201019 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta\u2010analysis (PRISMA) guidelines. A detailed literature search was done in PubMed and Embase from December 1, 2019, till May 1, 2020. Studies reporting cutaneous manifestations in COVID\u201019 patients were included. Irrespective of the heterogeneity of data, a random effects model with inverse\u2010variance approach was used for pooling the prevalence using meta package in R version 3.6.2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 15,143 articles, 2086 articles were selected for full\u2010text read. Forty\u2010three articles were selected for qualitative analysis, of which 10 articles (<jats:italic>N<\/jats:italic>\u00a0=\u00a01682) were included for meta\u2010analysis. The pooled prevalence of overall cutaneous lesions was 5.69 (95% confidence interval [CI]: 1.87\u201315.98; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> 88%). The pooled prevalence of other outcome parameters were as follows: viral exanthem\u2010like presentation 4.15 (95% CI: 1.33\u201312.23; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> 88%), maculopapular rash 3.81 (95% CI: 1.02\u201313.18; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> 87%), vesiculobullous lesions 1.67 (95% CI: 0.70\u20133.96; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> 0%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The estimated prevalence of cutaneous manifestations in COVID\u201019 was 5.69%. Other manifestations were urticaria, chilblain\u2010like lesions, livedo reticularis, and finger\/toe gangrene. Although it is premature to conclude the prevalence of the cutaneous manifestations during this ongoing pandemic, our report may be a stimulating factor for the physicians to perform further vigilant streamlined reporting of cutaneous manifestations in COVID\u201019 patients to estimate the final prevalence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.15154","type":"journal-article","created":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T22:13:27Z","timestamp":1600294407000},"page":"1358-1370","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The trend of cutaneous lesions during COVID\u201019 pandemic: lessons from a meta\u2010analysis and systematic review"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5324-1559","authenticated-orcid":false,"given":"Bandhala","family":"Rajan M.","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology &amp; Leprology All India Institute of Medical Sciences Jodhpur India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9318-1167","authenticated-orcid":false,"given":"Praveen","family":"Kumar\u2010M","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8191-2049","authenticated-orcid":false,"given":"Abhishek","family":"Bhardwaj","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology &amp; Leprology All India Institute of Medical Sciences Jodhpur India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,16]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"World Health Organization.Pneumonia of unknown cause \u2014 China.2020.https:\/\/www.who.int\/csr\/don\/05\u2010january\u20102020\u2010pneumonia\u2010of\u2010unkown\u2010cause\u2010china\/en\/(last accessed 13 May 2020)."},{"key":"e_1_2_7_3_1","unstructured":"WHO Director\u2010General's opening remarks at the media briefing on COVID\u201019\u2010March 2020.https:\/\/www.who.int\/dg\/speeches\/detail\/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020(last accessed 13 May 2020)."},{"key":"e_1_2_7_4_1","unstructured":"World Health Organization.Coronavirus disease (COVID\u201019) outbreak situation.2020.https:\/\/www.who.int\/emergencies\/diseases\/novel\u2010coronavirus\u20102019(last accessed 23 July 2020)."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2147"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2013.05.005"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001316"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.02.054"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2002032"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16387"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14243"},{"key":"e_1_2_7_12_1","unstructured":"WellsG SheaB O'ConnellD et al.The Newcastle\u2010Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta\u2010analyses.http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp(last accessed 22 July 2020)."},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.04.094"},{"volume-title":"R: A language and environment for statistical computing","year":"2019","author":"R Core Team","key":"e_1_2_7_14_1"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/ebmental-2019-300117"},{"volume-title":"readxl: Read Excel Files. 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