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We used the Oxford Center for Evidence\u2010Based Medicine Levels of Evidence to facilitate data synthesis. From 86 retrieved studies, we collated data on 2,560 patients with dermatologic manifestations of COVID\u201019. The most common findings were chilblains\/pernio\u2010like lesion (51.5%), erythematous maculopapular rashes (13.3%), and viral exanthem (7.7%). Average pediatric age was 12.9\u00a0years (SD 3.6) and adult was 34.2\u00a0years (SD 21.8). Average latency from time of upper respiratory illness symptoms to cutaneous findings was 1.5\u00a0days (SD 2.9) in children and 7.9\u00a0days (SD 10.7) in adults, ranging from \u22123 to 38\u00a0days. Roughly one\u2010tenth in both populations were otherwise asymptomatic or presented with only skin findings for the entirety of the disease course; 13.3% (pediatrics) and 5.3% (adults) presented with skin issues first. Dermatologic findings may play an important role in identifying cases early and serve as an important proxy to manage spread. Further prospective data collection with international prospective registries is needed.<\/jats:p>","DOI":"10.1111\/ijd.15168","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T18:09:57Z","timestamp":1604426997000},"page":"418-450","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Dermatologic manifestations of COVID\u201019: a comprehensive systematic review"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1299-6258","authenticated-orcid":false,"given":"Fatima N.","family":"Mirza","sequence":"first","affiliation":[{"name":"Department of Dermatology Yale School of Medicine Yale University New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amyn A.","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (Infectious Disease) Yale School of Medicine Yale University New Haven CT USA"},{"name":"Yale Institute for Global Health Yale University New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad B.","family":"Omer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (Infectious Disease) Yale School of Medicine Yale University New Haven CT USA"},{"name":"Yale Institute for Global Health Yale University New Haven CT USA"},{"name":"Department of Epidemiology of Microbial Diseases Yale School of Public Health Yale University New Haven CT USA"},{"name":"Yale School of Nursing Yale University Orange CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisha","family":"Sethi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yale School of Medicine Yale University New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30120-1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2002032"},{"key":"e_1_2_9_4_1","unstructured":"HowickJ ChalmersI GlasziouP et al.The 2011 Oxford CEBM levels of evidence.2011. 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