{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:11:41Z","timestamp":1792098701891,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T00:00:00Z","timestamp":1601337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atopic dermatitis (AD) is an allergic disease that affects individuals of various ages. Recently, the IL\u20104\/13 inhibitor dupilumab has gained regulatory approval for clinical use in AD patients. Dupilumab has been reported to reduce several markers of AD, including the serum levels of thymus and activation\u2010regulated chemokine (TARC\/CCL17), blood lactate dehydrogenase (LDH), and serum total immunoglobulin E (IgE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed data from 40 AD patients who were treated with dupilumab. Eczema Area and Severity Index (EASI), Investigator\u2019s Global Assessment (IGA), body surface area (BSA) scores, TARC, LDH, total IgE, and eosinophil count in peripheral blood were assessed for a total of 32\u00a0weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The EASI, IGA, and BSA scores improved significantly with treatment, indicating a reduction in AD severity. Serum TARC and LDH levels also significantly decreased with treatment. Serum IgE levels were unchanged at 2\u00a0weeks of treatment but decreased significantly between 4 and 32\u00a0weeks. The number of eosinophils in the peripheral blood decreased at 4, 16, and 32\u00a0weeks after treatment initiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Several studies have reported that serum TARC, LDH, and total IgE levels are reduced by dupilumab treatment. Our real\u2010world data are the first to demonstrate a reduction in blood eosinophilia in patients who receive clinical treatment with dupilumab.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.15183","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T06:56:02Z","timestamp":1601362562000},"page":"190-195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Dupilumab treatment ameliorates clinical and hematological symptoms, including blood eosinophilia, in patients with atopic dermatitis"],"prefix":"10.1111","volume":"60","author":[{"given":"Teruo","family":"Yamauchi","sequence":"first","affiliation":[{"name":"Department of Dermatology Showa University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Showa University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Seon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Showa University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Showa University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Seki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Showa University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tasuku","family":"Miwa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Showa University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kae","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Showa University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Saruta","sequence":"additional","affiliation":[{"name":"Department of Dermatology Showa University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Kitami","sequence":"additional","affiliation":[{"name":"Department of Dermatology Showa University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohiko","family":"Sueki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Showa University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9367-5167","authenticated-orcid":false,"given":"Hideaki","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Dermatology Showa University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0001-z"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0256-2"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2019.12.008"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.10.010"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15090"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18565"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2019.02.002"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18163"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18179"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18041"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.02.053"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15464"},{"key":"e_1_2_5_14_1","unstructured":"DUPIXENT\" (dupilumab).Highlights of prescribing information. 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Available from:https:\/\/www.ema.europa.eu\/documents\/product\u2010information\/dupixent\u2010epar\u2010product\u2010information_en.pdf(last accessed 16 April 2019)."},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.23.15036"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(98)01346-2"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.113237"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-011-1198-9"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000198"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2126"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12464"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23214"},{"key":"e_1_2_5_24_1","first-page":"270","article-title":"Atopic dermatitis in adults: clinical and epidemiological considerations","volume":"2013","author":"Orfali RL","year":"1992","journal-title":"Rev Assoc Med Bras"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17869"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1804093"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9061982"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1990.tb01679.x"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.15183","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijd.15183","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.15183","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T15:10:14Z","timestamp":1693408214000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.15183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,29]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1111\/ijd.15183"],"URL":"https:\/\/doi.org\/10.1111\/ijd.15183","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,29]]},"assertion":[{"value":"2020-05-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}