{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:48:15Z","timestamp":1781484495889,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T00:00:00Z","timestamp":1601856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>No randomized studies compared the efficacy and safety of modified Kligman\u2019s triple combination (TC) with 1,064\u00a0nm Q\u2010switched Nd\u2010YAG laser (QSNYL) in melasma in darker skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the efficacy and safety of QSNYL and TC in the treatment of melasma in Fitzpatrick skin types IV and V.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this split face randomized controlled trial, participants' cheeks were randomized to receive either weekly QSNYL (group A) or daily TC (group B) for 12\u00a0weeks, followed by 12\u00a0weeks of follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010eight patients completed the intervention, and 21 of them completed follow\u2010up. We found a significant but modest reduction in mean melanin index, modified Melasma Area Severity Index (MASI), and photographic and patient\u2019s assessment in both modalities (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.01). No significant differences were detected between the groups. All patients had reappearance of pigmentation by the end of follow\u2010up. Adverse reactions were significantly more in group B (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Limitation<\/jats:title><jats:p>The desired sample size could not be achieved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Relevence<\/jats:title><jats:p>No statistically significant differences were observed between QSNYL and TC as monotherapy in melasma. Reappearance of melasma is inevitable after stopping treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.15229","type":"journal-article","created":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T13:37:27Z","timestamp":1601905047000},"page":"1525-1530","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A split face randomized controlled trial comparing 1,064\u00a0nm Q\u2010switched Nd\u2010YAG laser and modified Kligman\u2019s formulation in patients with melasma in darker skin"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2425-0226","authenticated-orcid":false,"given":"Tanvi","family":"Dev","sequence":"first","affiliation":[{"name":"Department of Dermatology All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishnubhatla","family":"Sreenivas","sequence":"additional","affiliation":[{"name":"Department of 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