{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T16:23:07Z","timestamp":1756570987704,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T00:00:00Z","timestamp":1607558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The association between acne keloidalis nuchae (AKN) and thyroid diseases is yet to be investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the risk of developing hypothyroidism and hyperthyroidism among patients with AKN and to characterize the patients who have AKN and thyroid comorbidities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A population\u2010based cohort study was conducted comparing AKN patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a02,677) with age\u2010, gender\u2010, and ethnicity\u2010matched control subjects (<jats:italic>n<\/jats:italic>\u00a0=\u00a013,190) with regard to incident cases of hypothyroidism and hyperthyroidism. Adjusted hazard ratios (HRs) were estimated by Cox regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence rates of hypothyroidism among patients with AKN and controls were estimated at 2.15 (95% CI, 1.49\u20102.99) and 0.82 (95% CI, 0.66\u20101.00) cases\/1000 person\u2010years, respectively. The crude risk of developing incident hypothyroidism was 1.85\u2010fold greater in patients with AKN (HR, 1.85; 95% CI, 1.24\u20102.78; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003). The elevated risk persisted following the adjustment for putative confounders (adjusted HR, 1.72; 95% CI, 1.03\u20102.89; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.040). The risk of hyperthyroidism was comparable in patients with AKN and controls both in the crude (HR, 1.55; 95% CI, 0.57\u20104.22) and adjusted (adjusted HR, 1.92; 95% CI, 0.59\u20106.21) analyses. Patients with coexistent AKN and thyroid diseases were significantly older at the onset of AKN, had more prominent female preponderance, and had a higher burden of comorbidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with AKN are at an increased risk of hypothyroidism. Screening for hypothyroidism should be considered in AKN patients with a compatible clinical picture.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.15331","type":"journal-article","created":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T01:54:13Z","timestamp":1607651653000},"page":"466-470","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Acne keloidalis nuchae and thyroid diseases: a population\u2010based cohort study"],"prefix":"10.1111","volume":"60","author":[{"given":"Yuliya","family":"Valdman\u2010Grinshpoun","sequence":"first","affiliation":[{"name":"Department of Dermatology Sorokoa Medical Center Beer Sheva Israel"},{"name":"Siaal Research Center for Family Medicine and Primary Care Faculty of Health Sciences Ben\u2010Gurion University of the Negev Beer Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9971-9151","authenticated-orcid":false,"given":"Khalaf","family":"Kridin","sequence":"additional","affiliation":[{"name":"L\u00fcbeck Institute of Experimental Dermatology University of L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yochai","family":"Schonmann","sequence":"additional","affiliation":[{"name":"Clalit Health Services Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnon D.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Siaal Research Center for Family Medicine and Primary Care Faculty of Health Sciences Ben\u2010Gurion University of the Negev Beer Sheva Israel"},{"name":"Clalit Health Services Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13678"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.3668"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08146.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2165\/11537000-000000000-00000"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2012.01.005"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2018.18"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.13606"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1203475419874411"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.07.025"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2007.09.021"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2015.08.005"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2008.03121.x"},{"key":"e_1_2_6_14_1","unstructured":"RennertG PeterburgY.Prevalence of selected chronic diseases in Israel. 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