{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T07:13:34Z","timestamp":1784013214810,"version":"3.55.0"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T00:00:00Z","timestamp":1609113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Primary cutaneous CD4\u2010positive small\/medium pleomorphic T\u2010cell lymphoproliferative disorder has been defined as a type of lymphoproliferative disorder with indolent clinical course and excellent prognosis, yet a precise diagnosis is still hard to reach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of 22 patients including 16 females and six males was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The age of patients ranged from 5 to 79\u00a0years. The average age of all patients was 43.5, and the median age of all patients was 44.5. Two patients had multiple lesions, and others were presented with a solitary asymptomatic lesion. Besides general features, folliculotropism was observed in four cases. In addition to express CD3 and CD4, CD30 were positive to some extent. Some reactive cells could express CD8 and CD20. For follicular helper T\u2010cell markers, although CXCL\u201013 was negative in the stained cases (18\/18), the expression of PD\u20101 (12\/17), BCL\u20106 (12\/16) and CD10 (11\/15) was observed in most cases. In addition, we performed T\u2010cell receptor (TCR) rearrangement on five patients, and all of them showed monoclonality. Nearly all patients had excellent prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Primary cutaneous CD4\u2010positive small\/medium pleomorphic T\u2010cell lymphoproliferative disorder is complex. Some features like folliculotropism should also be noted. Besides, the expression of follicular helper T\u2010cell markers is not invariable. Moreover, CD8 positivity, Ki\u201067 index, and lesion number were perhaps not absolute prognostic indicators. To reach a diagnosis of this rare entity, putting all the pieces together is important.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.15372","type":"journal-article","created":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T18:06:30Z","timestamp":1609178790000},"page":"497-502","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinicopathological analysis of primary cutaneous CD4\u2010positive small\/medium pleomorphic T\u2010cell lymphoproliferative disorder: a retrospective study of 22 patients"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6718-9675","authenticated-orcid":false,"given":"Hao\u2010ze","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Pathology Institute of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology Institute of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing China"},{"name":"Department of Dermatology Central Theater General Hospital of Chinese People's Liberation Army Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010shu","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Pathology Institute of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Pathology Institute of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010qun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pathology Institute of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu\u2010lian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pathology Institute of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology Institute of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue\u2010si","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Pathology Institute of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010fang","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pathology Institute of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0857-7405","authenticated-orcid":false,"given":"Hao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology Institute of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-293050"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/ddg.13691","article-title":"Primary cutaneous CD4+ small\/medium pleomorphic T\u2010cell lymphoproliferative disorder: where do we stand? 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