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Mutations in genes affecting melanosome transfer, and melanocyte and keratinocyte differentiation have been implicated in the pathogenesis of this disease. These genes include <jats:italic>KRT5<\/jats:italic>, <jats:italic>POFUT1<\/jats:italic>, <jats:italic>POGLUT1<\/jats:italic> and, most recently, <jats:italic>PSENEN<\/jats:italic>. Dowling\u2010Degos disease can be found in isolation or with other associated findings, most notably hidradenitis suppurativa. This condition belongs to a spectrum of conditions that all result in reticulate hyperpigmentation that at times are hard to distinguish from each other. The most closely linked entity is Galli\u2010Galli, which is clinically indistinguishable from Dowling\u2010Degos disease and can only be distinguished by the presence of acantholysis on microscopy. Unfortunately, Dowling\u2010Degos disease is generally progressive and recalcitrant to treatment.<\/jats:p>","DOI":"10.1111\/ijd.15385","type":"journal-article","created":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T01:32:09Z","timestamp":1608859929000},"page":"944-950","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Dowling\u2010Degos disease: a review"],"prefix":"10.1111","volume":"60","author":[{"given":"Carla","family":"Stephan","sequence":"first","affiliation":[{"name":"Department of Dermatology American University of Beirut Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazen","family":"Kurban","sequence":"additional","affiliation":[{"name":"Department of Dermatology American University of Beirut Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ossama","family":"Abbas","sequence":"additional","affiliation":[{"name":"Department of 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