{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:51:31Z","timestamp":1790553091776,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T00:00:00Z","timestamp":1613779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lichen planus (LP) is considered to be an immune\u2010mediated disease of a not fully understood etiology. There are scarce data on the immune cells forming the band\u2010like infiltration in cutaneous LP (CLP). The objective of the current study was to investigate the immunohistochemical pattern of cells forming the infiltrate in CLP by assessing the immunoexpression of selected cell lineage markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The immunohistochemical analysis of the expression of CD4, CD8, CD20, CD56, CD68, c\u2010Kit, and Foxp3 was performed in formalin\u2010fixed paraffin\u2010embedded (FFPE) biopsy specimens from 14 cases of CLP and 11 healthy volunteers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The expression of CD4 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), CD8 (<jats:italic>P<\/jats:italic> &lt;\u00a00.001), CD68 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), Foxp3 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), CD56 (v\u00a0=\u00a00.019), and CD20 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) was significantly higher in lesional skin in CLP compared to healthy controls. The ratio of CD4+ to CD8+ cells in the infiltrate was 1.75:1. The expression of Foxp3, CD56, and CD20 was markedly lower than the expression of CD4 and CD8. There was no statistically significant difference in c\u2010Kit expression between CLP lesions and healthy skin (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.57).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found a wide variety of immune cells in the inflammatory infiltrate in CLP. The expression of CD4, CD8, CD68, Foxp3, CD56, and CD20 was significantly increased in CLP, while the expression of c\u2010Kit was comparable in lesional skin and controls. The presence of various cell populations, including T regulatory cells, NK cells, and B cells, may indicate a complex pathogenesis of CLP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.15437","type":"journal-article","created":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T04:48:54Z","timestamp":1613882934000},"page":"1097-1101","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Immunohistochemical analysis of the expression of selected cell lineage markers (CD4, CD8, CD68, c\u2010Kit, Foxp3, CD56, CD20) in cutaneous variant of lichen planus"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8268-0529","authenticated-orcid":false,"given":"Magdalena","family":"\u017bychowska","sequence":"first","affiliation":[{"name":"Department of Dermatology, Institute of Medical Sciences Medical College of Rzeszow University Rzesz\u00f3w Poland"},{"name":"Department of Dermatology, Venereology and Allergology Wroc\u0142aw Medical University Wroc\u0142aw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zdzislaw","family":"Wo\u017aniak","sequence":"additional","affiliation":[{"name":"Department of Pathomorphology Wroc\u0142aw Medical University Wroc\u0142aw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Baran","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology Wroc\u0142aw Medical University Wroc\u0142aw 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