{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T08:33:58Z","timestamp":1768638838956,"version":"3.49.0"},"reference-count":11,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,4,18]],"date-time":"2021-04-18T00:00:00Z","timestamp":1618704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to analyze changes in melanocyte density and epidermal thickness in vulvar lichen sclerosus (VLS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Vulvar skin tissues were collected from 15 VLS female patients in Beijing Hospital, classified into early (<jats:italic>n<\/jats:italic>\u00a0=\u00a07) and late VLS (<jats:italic>n<\/jats:italic>\u00a0=\u00a08) groups according to pathological manifestations. Melanocyte density and full epidermal and cell\u2010layer (from the bottom of the stratum corneum to that of the basal layer) thickness were calculated using an image analysis software. The control group was normal vulvar skin tissues from 15 females after plastic surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The early VLS (0.170\u00a0\u00b1\u00a00.071\u00a0\u00b5m) and late VLS (0.110\u00a0\u00b1\u00a00.035\u00a0\u00b5m) groups had significantly lower densities of epidermal melanocytes than the control group (0.275\u00a0\u00b1\u00a00.036) (<jats:italic>F<\/jats:italic>\u00a0=\u00a036.426, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The cell\u2010layer thickness did not differ between the early VLS (154.603\u00a0\u00b1\u00a0121.984\u00a0\u00b5m) and control (176.974\u00a0\u00b1\u00a080.296\u00a0\u00b5m) groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.899) but significantly decreased in the late VLS group (83.455\u00a0\u00b1\u00a037.129\u00a0\u00b5m) compared to the control group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Melanocyte density decreased in early and late VLS. The full epidermal and cell\u2010layer thickness did not significantly change in early VLS, but the cell\u2010layer thickness decreased in late VLS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.15555","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T04:59:20Z","timestamp":1618808360000},"page":"991-995","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Study of melanocyte density and epidermal thickness in vulvar lichen sclerosus lesions"],"prefix":"10.1111","volume":"60","author":[{"given":"Yu","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Dermatology Beijing Hospital National Center of Gerontology Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingqiu","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Beijing Hospital National Center of Gerontology Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2561-8347","authenticated-orcid":false,"given":"Ziyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Beijing Hospital National Center of Gerontology Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoman","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Beijing Hospital National Center of Gerontology Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianmin","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Beijing Hospital National Center of Gerontology Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijstd.IJSTD_23_19"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-012-0006-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14533"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13858"},{"key":"e_1_2_7_6_1","first-page":"355","article-title":"Clinical study of post\u2010inflammatory hypopigmented macular skin lesions","volume":"8","author":"Phulari Y","year":"2017","journal-title":"Int J Biomed Adv Res"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2011.04088.x"},{"key":"e_1_2_7_8_1","first-page":"283","article-title":"Clinical analysis of 129 cases of vulvar lichen sclerosus","volume":"51","author":"Wen W","year":"2018","journal-title":"Chin J Dermatol"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200204000-00001"},{"key":"e_1_2_7_10_1","volume-title":"Measurement and analysis of vulvar skin tissue thickness of Nonneoplastic epithelial disorders of vulvar","author":"Gu X","year":"2016"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015550310015419"},{"key":"e_1_2_7_12_1","first-page":"34","article-title":"Human epidermal thickness and skin aging","volume":"17","author":"Huang SS","year":"2011","journal-title":"Chin J Med Aesth Cosmet"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.15555","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijd.15555","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.15555","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T01:56:52Z","timestamp":1693360612000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.15555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,18]]},"references-count":11,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/ijd.15555"],"URL":"https:\/\/doi.org\/10.1111\/ijd.15555","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,18]]},"assertion":[{"value":"2020-12-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}