{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:26:16Z","timestamp":1793381176093,"version":"4.5.0"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T00:00:00Z","timestamp":1620000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to examine the effectiveness of botulinum toxin type A (BTX\u2010A) in the treatment of acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was conducted in 2018 on 12 patients, 10 females and two males, aged 35\u00a0years on average. The injections with BTX\u2010A were given during 2\u00a0weeks into the face skin in a dosage of 0.125\u20130.250 units.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Skin moisture indexes increased during the therapy by 4% (<jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00.05), and porosity decreased by 7% (<jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00.01). Maximal changes were recorded for the sulci and pigmentation of the skin, namely, its values decreased by 10 and 9%, respectively (<jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00.01). BTX\u2010A is recommended for an application not only in plastic surgeries but also for local correction of acne on the patient's skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A positive correlation was revealed between the duration of treatment and reduction of skin oiliness (0.87), pigmentation (0.78), skin sulci (0.84), and skin porosity (0.88), and negative correlation was established with increased skin moisture (\u22120.64). The obtained dependencies apply for the therapy period of up to 2\u00a0weeks. Pharmacological properties of BTX\u2010A allow recommending it as a drug used in post\u2010acne therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.15574","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T07:58:01Z","timestamp":1620028681000},"page":"1232-1241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The effectiveness of botulinum toxin type A (BTX\u2010A) in the treatment of facial skin oily seborrhea, enlarged pores, and symptom complex of post\u2010acne"],"prefix":"10.1111","volume":"60","author":[{"given":"Maria","family":"Shirshakova","sequence":"first","affiliation":[{"name":"Aesthetic clinics of Maria Shirshakova Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7837-1026","authenticated-orcid":false,"given":"Elena","family":"Morozova","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology I.M. Sechenov First Moscow State Medical University (Sechenov University) Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Sokolova","sequence":"additional","affiliation":[{"name":"Clinic: Centre of Medical Practice Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Pervykh","sequence":"additional","affiliation":[{"name":"Clinic of Evidence\u2010Based Medicine Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyudmila","family":"Smirnova","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology I.M. 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