{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T07:53:30Z","timestamp":1768895610685,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T00:00:00Z","timestamp":1618272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We compared demographic, clinical, treatment, and outcome characteristics of facial cutaneous leishmaniasis (CL) and non\u2010facial CL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective cohort study, polymerase chain reaction confirmed <jats:italic>Leishmania major<\/jats:italic> CL patients with \u22652 documented hospital visits, 2014\u20132019, were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 134 patients (34% and 66% with facial and non\u2010facial CL, respectively) were included. Facial CL patients were younger (43% vs. 8% &lt;18\u00a0years, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), with a higher proportion of females (41% vs. 25%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.07) compared with non\u2010facial CL. Clinical characteristics, including number and size of lesions and ulcer appearance, were similar in both the groups. Higher paromomycin\/methylbenzethonium chloride ointment treatment rates were noted in facial CL (85% vs. 64%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02). Intralesional sodium stibogluconate was given to 41% and 53% of facial CL and non\u2010facial CL patients, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.21). Cryotherapy and surgery were only used in non\u2010facial CL patients (5% and 1% of all CL cases, respectively). Systemic treatment (oral miltefosine, intravenous [IV] sodium stibogluconate, IV liposomal amphotericin B) was used in &lt;5% of the cases in both the groups. Overall, 84% of patients showed signs of improvement, including decreased lesion size or clinical improvement in 73% and 75% of patients, respectively. Only 5% of all cases healed without scarring. Outcome rates were similar in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Facial CL patients were younger and received more frequently <jats:italic>Leishmania<\/jats:italic>\u2010specific topical treatment than non\u2010facial CL patients. In contrast, the two groups were similar regarding clinical characteristics and outcome. These findings suggest differences in disease severity perception by patients and physicians.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.15582","type":"journal-article","created":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T13:56:35Z","timestamp":1618322195000},"page":"1109-1113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparison between cutaneous leishmaniasis patients with facial and non\u2010facial lesions"],"prefix":"10.1111","volume":"60","author":[{"given":"Rotem","family":"Yedidia Moser","sequence":"first","affiliation":[{"name":"Soroka University Medical Center Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7690-0991","authenticated-orcid":false,"given":"Shalom","family":"Ben\u2010Shimol","sequence":"additional","affiliation":[{"name":"Soroka University Medical Center Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orli","family":"Sagi","sequence":"additional","affiliation":[{"name":"Soroka University Medical Center Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6646-9061","authenticated-orcid":false,"given":"Amir","family":"Horev","sequence":"additional","affiliation":[{"name":"Soroka University Medical Center Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31204-2"},{"key":"e_1_2_5_3_1","first-page":"626","article-title":"Cutaneous leishmaniasis in Israel 2016 \u2010 an update","volume":"155","author":"Solomon M","year":"2016","journal-title":"Harefuah"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365548.2014.977342"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67629-5"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2017.2119"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-017-0267-5"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-018-5260-9"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.12.047"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-9062.263723"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1202657"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13149-016-0475-4"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005090"},{"key":"e_1_2_5_14_1","first-page":"458","article-title":"Cutaneous leishmaniasis treated with ambisome (liposomal amphotericin B)","volume":"151","author":"Ben\u2010Shimol S","year":"2012","journal-title":"Harefuah"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-016-1919-6"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.15-0860"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/tmi.12928"},{"key":"e_1_2_5_18_1","first-page":"353","article-title":"Treatment of cutaneous leishmaniasis with aminosidine (paromomycin) ointment: double\u2010blind, randomized trial in the Islamic Republic of Iran","volume":"81","author":"Asilian A","year":"2003","journal-title":"Bull World Health Organ"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(92)70175-F"},{"key":"e_1_2_5_20_1","first-page":"172","article-title":"Sporotrichoid abscesses: a rare form of recurrent cutaneous leishmaniasis in an infant's face","volume":"18","author":"Nabli N","year":"2020","journal-title":"Skinmed"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0008550"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1590\/0037-8682-0211-2018"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.15582","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijd.15582","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.15582","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T23:12:23Z","timestamp":1693350743000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.15582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,13]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/ijd.15582"],"URL":"https:\/\/doi.org\/10.1111\/ijd.15582","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,13]]},"assertion":[{"value":"2020-09-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}