{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:49:39Z","timestamp":1780598979324,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:00:00Z","timestamp":1622160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Infection is an important complication of epidermolysis bullosa (EB), and <jats:italic>Staphylococcus<\/jats:italic> <jats:italic>aureus<\/jats:italic> has been pointed out as the most common pathogen among this population. The objective of this study was to investigate the prevalence and antimicrobial resistance profile of <jats:italic>S<\/jats:italic>.\u00a0<jats:italic>aureus<\/jats:italic> colonizing EB patients in Brazil.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional multicenter study was conducted between December 2015 and December 2017. We included a total of 89 individuals with EB from medical centers across Brazil. Data were obtained through clinical and bacteriological investigation. <jats:italic>S<\/jats:italic>.\u00a0<jats:italic>aureus<\/jats:italic> were identified by biochemical tests. The <jats:italic>nuc<\/jats:italic> and <jats:italic>mec<\/jats:italic><jats:italic>A<\/jats:italic> genes were confirmed by PCR assay. Antimicrobial susceptibility was investigated by disk diffusion method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall prevalence of <jats:italic>S<\/jats:italic>.\u00a0<jats:italic>aureus<\/jats:italic> was 51.7% (46\/89). Methicillin\u2010resistant <jats:italic>S<\/jats:italic>.\u00a0<jats:italic>aureus<\/jats:italic> (MRSA) was detected in 24.7% (19\/77) of all <jats:italic>S<\/jats:italic>.\u00a0<jats:italic>aureus<\/jats:italic> isolates, colonizing 15.7% (14\/89) of all patients. Community\u2010associated (CA)\u2010MRSA strains were resistant against sulfamethoxazole\/trimethoprim and levofloxacin (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05%). <jats:italic>S<\/jats:italic>.\u00a0<jats:italic>aureus<\/jats:italic> colonization of the nares and belly button represented a 3.4 times higher risk of simultaneous skin lesion colonization (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The high frequency of MRSA colonizing patients with EB is alarming considering its association with life\u2010threatening complications and poorer outcomes. EB patients are at increased risk of colonization and infection by <jats:italic>Staphylococcu<\/jats:italic>s aureus and CA\u2010MRSA. Getting to know <jats:italic>S<\/jats:italic>.\u00a0<jats:italic>aureus<\/jats:italic> carriage sites and its antimicrobial susceptibility profile is key when planning new individualized and more effective prophylactic and therapeutic measures.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.15634","type":"journal-article","created":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T13:15:51Z","timestamp":1622207751000},"page":"1126-1130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Prevalence and antimicrobial resistance profile of <i>Staphylococcus aureus<\/i> in inherited epidermolysis bullosa: a cross\u2010sectional multicenter study in Brazil"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8717-7375","authenticated-orcid":false,"given":"Juliana T.","family":"Santin","sequence":"first","affiliation":[{"name":"Postgraduate Program in Child and Adolescent Health Faculty of Medicine Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6626-934X","authenticated-orcid":false,"given":"Luiza M.","family":"Mariath","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Genetics and Molecular Biology Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5597-0790","authenticated-orcid":false,"given":"Adriana M.","family":"Rossato","sequence":"additional","affiliation":[{"name":"Basic Health Department Universidade Federal de Ci\u00eancias da Sau\u0301de de Porto Alegre (UFCSPA) Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2428-0460","authenticated-orcid":false,"given":"Lav\u00ednia","family":"Schuler\u2010Faccini","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Genetics and Molecular Biology Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6287-6302","authenticated-orcid":false,"given":"Ana E.","family":"Kiszewski","sequence":"additional","affiliation":[{"name":"Service of Dermatology Irmandade Santa Casa de Miseric\u00f3rdia de Porto Alegre\/Universidade Federal de Ci\u00eancias da Sau\u0301de de Porto Alegre (UFCSPA) Porto Alegre Rio Grande do Sul Brazil"},{"name":"Section\u00a0of Pediatric Dermatology Hospital da Crian\u00e7a Santo Ant\u00f4nio Irmandade da Santa Casa de Miseric\u00f3rdia de Porto Alegre Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-5-12"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200203060-00001"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13668"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18921"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.01.903"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.02.004"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962013000200001"},{"key":"e_1_2_6_9_1","first-page":"41","article-title":"Recessive dystrophic epidermolysis bullosa: a review of disease pathogenesis and update on future therapies","volume":"8","author":"Soro L","year":"2015","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05463.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.06.039"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.03.052"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2010.01.004"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.03.053"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(90)70120-7"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.14202\/vetworld.2016.501-506"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00165-06"},{"key":"e_1_2_6_18_1","unstructured":"Institute C and LS.Performance standards for antimicrobial susceptibility testing: twenty\u2010fourth informational supplement. 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