{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T21:13:30Z","timestamp":1772918010673,"version":"3.50.1"},"reference-count":57,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T00:00:00Z","timestamp":1621468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Taurine\u2010upregulated gene 1 (TUG1) is one of the long noncoding RNAs (lncRNAs) that plays a role in melanogenesis. MicroRNA\u2010377 (miRNA\u2010377) is a conserved noncoding RNA that regulates angiogenesis and promotes oxidative stress. Peroxisome proliferator\u2010activated receptors (PPARs) are components of the nuclear hormone receptor superfamily. PPAR\u2010\u03b3 activators stimulate melanogenesis. Interleukin (IL)\u201017 has been implicated in the pathogenesis of several immunological diseases. This work aimed at detecting the expression levels of lncRNA TUG1, miRNA\u2010377, PPAR\u2010\u03b3, and IL\u201017 among vitiligo subjects and to investigate their possible role in the pathogenesis of vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was conducted on 30 healthy controls and 30 vitiligo patients. LncRNA TUG1 and miRNA\u2010377 were detected in serum by real\u2010time polymerase chain reaction (PCR). Also, expressions of PPAR\u2010\u03b3 and IL\u201017 were assessed in tissue by real\u2010time PCR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LncRNA TUG1 and PPAR\u2010\u03b3 levels were significantly downregulated in the vitiligo group compared with the control group. On the other hand, miRNA\u2010377 and IL\u201017 were significantly upregulated in the vitiligo group compared with the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrated the dysregulated expressions of lncRNA TUG1 and miRNA\u2010377 in patients with vitiligo suggesting that both contributed to the pathogenesis of vitiligo that might be through PPAR\u2010\u03b3 downregulation and IL\u201017 upregulation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.15669","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T12:29:56Z","timestamp":1621513796000},"page":"199-207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Association between long noncoding RNA taurine\u2010upregulated gene 1 and microRNA\u2010377 in 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