{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T01:17:17Z","timestamp":1789348637931,"version":"build-2803163510"},"reference-count":84,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T00:00:00Z","timestamp":1622592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Squamous cell carcinoma (SCC) can present as a rare complication of longstanding hidradenitis suppurativa (HS) lesions. Limited data exist on characteristics and outcomes of SCC development within HS lesions. The purpose of this review is to conduct a literature review of previously reported cases of SCC development in pre\u2010existing HS lesions. EMBASE and MEDLINE searches were conducted in OVID on June 25, 2020, to yield 59 studies. Of the 95 patients (mean age: 52.9\u00a0years) who developed a total of 122 SCCs within HS lesions, the majority were males (77.9%,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a074\/95). The most common sites of SCC were the gluteal region (47.5%,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a058\/122), the perianal region (18.9%,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a023\/122), and the genitals (13.9%,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a017\/122). The mean duration between HS onset and SCC development was 25.5\u00a0years. Of the patients that had outcomes reported, 54.0% (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a034\/63) experienced SCC metastasis, 43.1% (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a028\/65) experienced SCC recurrences, and 58.7% (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a044\/75) experienced a mortality outcome. The most common documented reasons for death included metastasis (34.1%,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a015\/44) and sepsis (13.6%,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a06\/44). Patients with longstanding HS lesions can develop SCCs with a high rate of metastasis and mortality. Thus, chronic HS lesions, especially in the gluteal, perianal, genital, and perineal regions, should be monitored regularly for timely SCC diagnosis and management.\n                  <\/jats:p>","DOI":"10.1111\/ijd.15677","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T08:26:06Z","timestamp":1622622366000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Squamous cell carcinoma arising within hidradenitis suppurativa: a literature review"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2252-5663","authenticated-orcid":false,"given":"Muskaan","family":"Sachdeva","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asfandyar","family":"Mufti","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Medicine University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiba","family":"Zaaroura","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Medicine University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abrahim","family":"Abduelmula","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Western Ontario London ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael Paolo","family":"Lansang","sequence":"additional","affiliation":[{"name":"Bachelors of Health Sciences McMaster University Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Bagit","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Brock University St. Catharines ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raed","family":"Alhusayen","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Medicine University of Toronto Toronto ON Canada"},{"name":"Sunnybrook Health Sciences Centre Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16231"},{"key":"e_1_2_5_3_1","first-page":"1547","article-title":"Hidradenitis suppurativa: a treatment challenge","volume":"72","author":"Shah NR","year":"2005","journal-title":"Am Fam Physician"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2005.06.053"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjps.1999.3285"},{"key":"e_1_2_5_6_1","first-page":"1017","article-title":"Hidradenitis suppurativa: review of the pathogenesis and treatment","volume":"15","author":"Kurayev A","year":"2016","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_5_7_1","first-page":"1514","volume-title":"Dermatology","author":"Hurley HJ","year":"1992"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.15570\/actaapa.2018.5"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12671"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.5070\/D3214026278"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_5_12_1","unstructured":"AM.Oxford Centre for Evidence\u2010based Medicine \u2010 Levels of Evidence (March 2009)[Internet].CEBM 2016. 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