{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:18:41Z","timestamp":1792603121363,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T00:00:00Z","timestamp":1622851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The current scenario and position of laser and light\u2010based therapies (LLBT) in the therapeutic rosacea scheme are lacking evidence\u2010based recommendations and comparisons on efficacy and tolerability among different devices. This article aimed to systematically compare the efficacy, acceptability, and tolerability of the pulsed dye laser (PDL) versus other devices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A literature search was conducted in March 2020. Four domains were analyzed throughout the following six outcomes: Spectrophotometer erythema index and percentage of reduction for background erythema, telangiectasia grading scale for telangiectasias, visual analog scale for pain, and physician's assessment and patient\u2019s satisfaction for treatment success.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our search yielded 423 potentially relevant studies. After removing the excluded and duplicated records, 12 records were assessed for eligibility in the meta\u2010analysis. Erythema (RR:0.38 95%CI: \u22120.20\u20100.95), telangiectasias (RR:0.54 95%CI: \u22120.87\u20101.94), and the treatment success throughout the physician\u2019s assessment (RR:1.23 95%CI: 0.74\u20102.04) and the patient\u2019s satisfaction (RR:1.15 95%CI: 0.73\u20101.82) were not significantly different between pulsed dye laser and other LLBT. In the pain domain, PDL was as painful as other LLBT (RR:\u20100.23 95%CI: \u22120.96\u20100.49) but more painful than neodymium: yttrium\u2010aluminum\u2010garnet laser (RR:0.84 95%CI: 0.53\u20101.14) and less than intense pulsed light (RR:\u20101.18 95%CI: \u22121.56\u22120.80).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This work based on previously published literature demonstrates that the quality of evidence to support any recommendation on LLBT in rosacea is low\u2010to\u2010moderate. Among all the available devices, PDL holds the most robust evidence, although in the meta\u2010analysis the effectiveness was comparable to other LLBT, such as neodymium: yttrium\u2010aluminum\u2010garnet laser (Nd\u2010YAG) or IPL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.15680","type":"journal-article","created":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T10:38:52Z","timestamp":1622889532000},"page":"216-225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Light\u2010based therapies in the management of rosacea: a systematic review with meta\u2010analysis"],"prefix":"10.1111","volume":"61","author":[{"given":"Husein","family":"Husein\u2010ElAhmed","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Hospital de Baza Granada Spain"},{"name":"Translational Research Institute Hamad Medical Corporation Doha 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