{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:45:21Z","timestamp":1791938721517,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T00:00:00Z","timestamp":1625616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne vulgaris is a disease that inflames the sebaceous gland with multiple etiologies. Many proinflammatory adipokines contribute to this pathogenesis. Resistin is a proinflammatory mediator that activates kappa B, a nuclear factor, and c\u2010Jun N\u2010terminal kinases pathways inducing toll\u2010like receptor\u20102, interleukin\u20101, 6, and tumor necrosis factor alpha. Resistin gene affects the promoter and intron regions' polymorphisms' expression levels. We aimed to study the association of resistin gene polymorphisms (<jats:italic>RETN<\/jats:italic> \u2010420 C\/G) and the development of acne vulgaris and whether it is associated with serum resistin levels and disease severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and methods<\/jats:title><jats:p>Resistin (<jats:italic>RETN<\/jats:italic>) gene (<jats:italic>rs1862513<\/jats:italic>) genotypes were identified using restriction fragment length polymorphism (RFLP), and serum resistin presence was assessed by enzyme\u2010linked immunosorbent assay in 40 patients with acne vulgaris and 40 age\u2010 and sex\u2010matched healthy controls as a cross\u2010reference. Patients were divided into mild, moderate, and severe groups. Global Acne Grading System (GAGS) was used to assess the severity of acne vulgaris.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CG and GG genotypes were present in cases (<jats:italic>P<\/jats:italic>\u2009=\u20090.006) odds ratio (OR)<jats:sub>1<\/jats:sub>\u2009=\u20094.43; 95% confidence interval (CI) (1.53, 12.7) and OR<jats:sub>2<\/jats:sub>\u2009=\u20095.47; 95% CI (0.99, 30.1); G\u2010allele statistically dominated in the patient group where <jats:italic>P<\/jats:italic>\u2009=\u20090.001 and OR\u2009=\u20093.57; 95% CI (1.63, 7.80). A positive significant relationship between <jats:italic>RETN<\/jats:italic> genotypes and serum resistin levels and GAGS score was present.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>RETN<\/jats:italic> genes <jats:italic>rs1862513<\/jats:italic> GG and G allele are correlated to acne vulgaris development and severity in a sample of the Egyptian population. This study comprised a small sample size. The cases may not accurately represent the general population; only one clinic was enrolled in the study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.15727","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T05:06:45Z","timestamp":1625720805000},"page":"1270-1277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Serum resistin levels and resistin gene polymorphism in patients with acne vulgaris: does it correlate with disease severity?"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7126-8261","authenticated-orcid":false,"given":"Wafaa A.","family":"Shehata","sequence":"first","affiliation":[{"name":"Dermatology, Andrology and STDs Department Menoufia University Shebin EL\u2010Kom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa","family":"Maraee","sequence":"additional","affiliation":[{"name":"Dermatology, Andrology and STDs Department Menoufia University Shebin EL\u2010Kom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tagreed A. A.","family":"Wahab","sequence":"additional","affiliation":[{"name":"General Practitioner in Health Sector Shebin EL\u2010Kom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania","family":"Azmy","sequence":"additional","affiliation":[{"name":"Medical Biochemistry and Molecular Biology Department Menoufia University Shebin EL\u2010Kom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.06.045"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-69375-8_28"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.08.015"},{"key":"e_1_2_7_5_1","first-page":"44","article-title":"The pathogenesis of acne","volume":"13","author":"Knor T","year":"2005","journal-title":"Acta Dermatovenerol Croat"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2009.03.012"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-014-0099-z"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/35053000"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.07.073"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.9.5789"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700743"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08655.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2012.07.001"},{"key":"e_1_2_7_14_1","first-page":"526","article-title":"The RETN gene rs1862513 polymorphism as a novel predisposing marker for familial Acne vulgaris in a Pakistani population","volume":"18","author":"Hussain S","year":"2015","journal-title":"Iran J Basic Med Sci"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2715"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1086\/424761"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13776"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1586\/17469872.3.5.595"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1997.00099.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.110753"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.2010.00635.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-016-1626-y"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.20546\/ijcmas.2016.512.045"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-003-1319-x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-1936"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10528-015-9678-9"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.22227"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-1339"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40200-015-0165-y"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.15727","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijd.15727","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.15727","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T07:28:21Z","timestamp":1693294101000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.15727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,7]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1111\/ijd.15727"],"URL":"https:\/\/doi.org\/10.1111\/ijd.15727","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,7]]},"assertion":[{"value":"2021-01-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}