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It competes with androgens, especially dihydrotestosterone, for androgen\u2010receptor binding and limits their binding, thus inhibiting downstream signaling of pathways involved in the pathogenesis of acne. It inhibits androgen receptor\u2010regulated gene transcription, and antagonizes lipid and inflammatory cytokine production in a dose\u2010dependent manner in human primary sebocytes. Clascoterone is commercially available as 1% (10\u2009mg\/g) cream. Adverse effects of topical clascoterone are mild and infrequent, and are mostly limited to local skin reactions. Long\u2010term safety studies have shown an absence of systemic antiandrogenic effects like reduced libido or feminization in male participants. Clascoterone seems a promising topical drug with a novel mechanism of action that could be added to the armamentarium of therapies for acne.<\/jats:p>","DOI":"10.1111\/ijd.15752","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T18:33:37Z","timestamp":1625855617000},"page":"1561-1565","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Clascoterone: a new topical anti\u2010androgen for acne management"],"prefix":"10.1111","volume":"60","author":[{"given":"Parvathy","family":"Santhosh","sequence":"first","affiliation":[{"name":"Department of Dermatology Malabar Medical College Hospital and Research Centre Kozhikode India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamatha","family":"George","sequence":"additional","affiliation":[{"name":"Department of Dermatology Malabar Medical College Hospital and Research Centre Kozhikode India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,9]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13462"},{"key":"e_1_2_14_3_1","first-page":"589","volume-title":"Pediatric Dermatology","author":"Gelmetti CC","year":"2003"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.06.045"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.199581"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14374"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijwd.2017.10.006"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-020-01417-6"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-012-1265-x"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2004.03.004"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2016.10.004"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2015.04.005"},{"key":"e_1_2_14_13_1","first-page":"1005","article-title":"Androgens have forgotten and emerging roles outside of their reproductive functions, with implications for diseases and disorders","volume":"1","author":"Dart D","year":"2014","journal-title":"J Endocr Disord"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000017866"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.8.4279"},{"key":"e_1_2_14_16_1","first-page":"181","article-title":"Acne vulgaris related to androgens \u2010 a review","volume":"23","author":"Khondker L","year":"2014","journal-title":"Mymensingh Med J"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S114830"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.110765"},{"key":"e_1_2_14_19_1","unstructured":"PubChem.Cortexolone 17alpha\u2010propionate.https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/11750009. 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