{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T10:19:36Z","timestamp":1782296376618,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T00:00:00Z","timestamp":1632268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>HLA\u2010B*15:11 is associated with carbamazepine (CBZ)\u2010induced severe cutaneous adverse drug reactions (SCARs) in Japanese and some Asian populations, but such data remains relatively limited in Chinese. Routine HLA\u2010B*15:02 screening is mandatory before CBZ commencement, however, SCARs related to CBZ were still observed in non\u2010HLA*B\u201015:02 carriers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to find out the prevalence of HLA\u2010B*15:11 in Chinese patients and its associations with CBZ\u2010induced SCARs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We screened 8,328 blood samples collected for HLA allele typing before CBZ commencement during the period of January 2014 to December 2019. In HLA\u2010B*15:02 negative Chinese patients, HLA\u2010B*15:11 status were further screened, and the incidence of SCARs in the CBZ group was compared with the control group without CBZ use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>In this cohort, 1416 out of 8328 patients (17%) tested HLA\u2010B*15:02 positive and were advised to avoid CBZ, while 80 (0.96%) were found to be HLA\u2010B*15:11 positive. In 6911 (83%) patients who tested HLA\u2010B*15:02 negative, 70 (1.01%) were HLA\u2010B*15:11 positive. Five out of 70 (7.14%) patients had SCARs. The incidence of SCARs in HLA\u2010B*15:11 carriers who received CBZ was significantly higher than those without CBZ (17.4% [4\/23] vs. 2.13% [1\/47], <jats:italic>P<\/jats:italic>\u2009=\u20090.037*). The odds ratio was 9.68 (95% CI 1.02\u201392.4, <jats:italic>P<\/jats:italic>\u2009=\u20090.048*). These included: one Stevens\u2010Johnson syndrome (SJS), two DRESS, and one MPE after CBZ use, while one developed MPE after phenytoin use in control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HLA\u2010B*15:11 is a potential risk factor of CBZ\u2010induced SCARs in HLA\u2010B*15:02 negative Chinese patients. Further screening of HLA\u2010B*15:11 status in those HLA\u2010B*15:02 negative patients is recommended to avoid undesirable SCARs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.15792","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T01:58:30Z","timestamp":1632362310000},"page":"184-190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["HLA\u2010B*15:11 status and carbamazepine\u2010induced severe cutaneous adverse drug reactions in HLA\u2010B*15:02 negative Chinese"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4603-6407","authenticated-orcid":false,"given":"Christina S. M.","family":"Wong","sequence":"first","affiliation":[{"name":"Division of Dermatology Department of Medicine The Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8179-8293","authenticated-orcid":false,"given":"Desmond Y. H.","family":"Yap","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine The Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6797-6898","authenticated-orcid":false,"given":"Patrick","family":"Ip","sequence":"additional","affiliation":[{"name":"Department of Paediatrics &amp; Adolescent Medicine The Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8396-2368","authenticated-orcid":false,"given":"Wilfred H. S.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Paediatrics &amp; Adolescent Medicine The Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0333-0059","authenticated-orcid":false,"given":"Gilbert T.","family":"Chua","sequence":"additional","affiliation":[{"name":"Department of Paediatrics &amp; Adolescent Medicine The Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0278-1763","authenticated-orcid":false,"given":"Chi\u2010Keung","family":"Yeung","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Medicine The Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9657-1435","authenticated-orcid":false,"given":"Henry H. 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