{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T20:54:10Z","timestamp":1774472050757,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T00:00:00Z","timestamp":1631750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Interleukin\u201017 (IL\u201017) is a pro\u2010inflammatory mediator which its excess secretion by immune cells is found in many chronic autoimmune diseases. This survey is aimed to compare the amount and pattern of distribution of IL\u201017 positive cells in lichen planopilaris (LPP) and discoid lupus erythematosus (DLE) which are of the most frequent causes of primary cicatricial alopecia (CA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Biopsies of lesional scalp skin from adult LPP (n = 30), DLE patients (n = 19), and control scalp skin (n = 18) were analyzed by immunohistochemistry (IHC) method using rabbit polyclonal antibody against IL\u201017. Cells stained positive for IL\u201017 and their pattern of distribution were assessed and compared between these groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean of IL\u201017 positive cell counts per high power field (HPF) in both LPP and DLE groups was significantly higher in comparison with the control group (both <jats:italic>p<\/jats:italic> &lt; .0001). The LPP group had higher values of IL\u201017 positive cell counts per HPF (47.56 \u00b1 13.37) compared to the DLE group (22.21 \u00b1 11.06) (<jats:italic>p<\/jats:italic> &lt; .0001). More than 30 IL\u201017 positive cell counts in IHC have a sensitivity of 90% and a specificity of 78% for differentiating LPP from DLE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that IL\u201017 is effective in the pathogenesis of DLE and LPP and its role is more prominent in LPP. IL\u201017 positive cells in IHC can distinguish DLE from LPP with satisfactory sensitivity and specificity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.15885","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T21:08:36Z","timestamp":1631826516000},"page":"647-652","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The role of interleukin\u201017 (IL\u201017) in the pathogenesis of discoid lupus erythematosus and lichen planopilaris: is immunohistochemistry for IL\u201017 a promising way to differentiate these entities?"],"prefix":"10.1111","volume":"61","author":[{"given":"Mohammad","family":"Shahidi Dadras","sequence":"first","affiliation":[{"name":"Skin Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azadeh","family":"Rakhshan","sequence":"additional","affiliation":[{"name":"Skin Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"Department of pathology Shohada\u2010e\u2010Tajrish Educational Hospital, School of Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahar","family":"Dadkhahfar","sequence":"additional","affiliation":[{"name":"Skin Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara","family":"Barat","sequence":"additional","affiliation":[{"name":"Skin Research Center Shahid Beheshti University of Medical Sciences  Tehran 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