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The only oral drug available (miltefosine) has shown resistance, is expensive, and is not available in many endemic countries. Thus, the development of an oral medicine may solve many of these issues. Based on that, this review aimed to investigate which therapeutic alternatives have been studied for the development of oral drugs for the treatment of cutaneous leishmaniasis. A literature search for keywords \u201cleishmania and oral\u201d was performed in PubMed and ScienceDirect, considering articles published in the last 5\u2009years. The articles were selected based on the objective of the review. The main problem in the current treatment of leishmaniasis is the administration of injectables, since it requires patients to travel to health centers, hospitalization, and professional administration, conditions that are not adapted to the socioeconomic reality of patients. Therefore, many research studies have evaluated oral alternatives for the treatment of cutaneous leishmaniasis. The main tested approaches were obtaining new molecules, repositioning drugs, and new formulations of old drugs. The prospects are encouraging but still require more <jats:italic>in\u2009vivo<\/jats:italic> bioavailability and clinical trials.<\/jats:p>","DOI":"10.1111\/ijd.15902","type":"journal-article","created":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T16:04:11Z","timestamp":1631462651000},"page":"89-98","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cutaneous leishmaniasis: new oral therapeutic approaches under development"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2021-5418","authenticated-orcid":false,"given":"Myla L\u00f4bo","family":"de Souza","sequence":"first","affiliation":[{"name":"Laboratory of Drug Technology Department of Pharmaceutical Sciences Federal University of Pernambuco Av. 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