{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:31:23Z","timestamp":1793413883196,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T00:00:00Z","timestamp":1635465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Alopecia areata (AA) is an autoimmune disorder characterized by nonscarring hair loss that can involve the scalp, face, and body. Severe AA subtypes have a poorer prognosis and can be challenging to treat. Tofacitinib, a recently introduced Janus kinase inhibitor, has shown positive results in treating AA. This multicenter study demonstrates the efficacy of tofacitinib and the patient response rate in a Saudi population. It also highlights patient characteristics that may serve as predictors of the therapeutic response to tofacitinib.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective cohort study design was utilized. Study participants were included from three medical centers in Riyadh, Saudi Arabia. The Severity of Alopecia Tool (SALT) score was used to assess the percentage of hair loss at baseline and the percentage of hair regrowth at 3 and 6\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The sample size was 68 with an average baseline SALT score of 76.8\u2009\u00b1\u200927.6%. Data at 6\u2009months were available for 45 patients. Of these, 62.2% achieved a SALT score of &gt;50%. Patients with a score of &lt;50% had a significantly higher baseline SALT score compared to patients with &gt;50% score. The past use of systemic steroids was associated with a diminished response to therapy (<jats:italic>P<\/jats:italic>\u2009=\u20090.015). The response to therapy was significantly higher in patients with AA compared to alopecia totalis and alopecia universalis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Tofacitinib is an effective and well\u2010tolerated treatment for severe AA and exhibits a good safety profile.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.15917","type":"journal-article","created":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T04:27:12Z","timestamp":1635568032000},"page":"886-894","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Alopecia areata and tofacitinib: a prospective multicenter study from a Saudi population"],"prefix":"10.1111","volume":"61","author":[{"given":"Alanoud","family":"AlMarzoug","sequence":"first","affiliation":[{"name":"Department of Dermatology King Abdulaziz Medical City  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May","family":"AlOrainy","sequence":"additional","affiliation":[{"name":"Department of Dermatology Security Forces Hospital  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lama","family":"AlTawil","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Dermatologic Surgery Prince Sultan Military Medical City  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghada","family":"AlHayaza","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Dermatologic Surgery Prince Sultan Military Medical City  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha","family":"AlAnazi","sequence":"additional","affiliation":[{"name":"College of Medicine King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"AlIssa","sequence":"additional","affiliation":[{"name":"Dermatology Derma Clinic  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afaf","family":"AlSheikh","sequence":"additional","affiliation":[{"name":"Department of Dermatology King Abdulaziz Medical City  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"AlKhalifah","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Dermatologic Surgery Prince Sultan Military Medical City  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruaa","family":"AlHarithy","sequence":"additional","affiliation":[{"name":"Department of Dermatology Security Forces Hospital  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a013615"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3645"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.08.032"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.10347"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S53985"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.10.032"},{"key":"e_1_2_5_8_1","first-page":"674","article-title":"Intralesional triamcinolone acetonide in alopecia areata amongst 62 Saudi Arabs","volume":"71","author":"Kubeyinje EP","year":"1994","journal-title":"East Afr Med J"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15937"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S138677"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1112072"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen\u20102017\u2010000491"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3645"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.260"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijt.ijt_21_18"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.89776"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.0001"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13060"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.2484"},{"key":"e_1_2_5_20_1","unstructured":"R: the R project for statistical computing. 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