{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:39:07Z","timestamp":1790653147680,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Treatment of vitiligo with intralesional steroid (ILS) injections has shown to be successful in quite a few studies. It is a simple and safe treatment when used with caution with a better response in localized lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of the present study is to explore the efficacy and safety of using different concentrations of intralesional corticosteroid combined with NB\u2010UVB phototherapy in the treatment of non\u2010segmental vitiligo (NSV) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Twenty patients with non\u2010segmental vitiligo were subjected to different concentrations of ILS injections (triamcinolone acetonide); that was carried out monthly for six sessions. All patients were also subjected to twice\u2010weekly sessions of NB\u2010UVB for 6\u2009months. Punch biopsy was taken from each patch before and at the end of treatment sessions. Each biopsy was stained with hematoxylin and eosin (H&amp;E), Orcein, and Masson's trichrome stains.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant difference between all groups in their repigmentation response (<jats:italic>P<\/jats:italic>\u2009=\u20090.017). After treatment, the epidermal thickness (histometry) was decreased (epidermal atrophy), especially with concentrations of 2.5 and 5\u2009mg\/ml of intralesional triamcinolone acetonide injection with decreased and disorganized collagen fibers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intralesional corticosteroid injections combined with NB\u2010UVB showed a good and well\u2010tolerated therapeutic option for vitiligo. The concentrations of 0.625 and 1.25\u2009mg\/ml of triamcinolone acetonide were the safest with fewer side effects and complications. However, higher concentrations of 2.5 and 5\u2009mg\/ml were more effective but with more side effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.15940","type":"journal-article","created":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T14:01:38Z","timestamp":1634220098000},"page":"582-590","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The use of intralesional corticosteroid combined with narrowband ultraviolet B in vitiligo treatment: clinical, histopathologic, and histometric evaluation"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8921-2442","authenticated-orcid":false,"given":"Moetaz","family":"El\u2010Domyati","sequence":"first","affiliation":[{"name":"Department of Dermatology, STDs and Andrology Faculty of Medicine Minia University Al\u2010Minya Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9563-2761","authenticated-orcid":false,"given":"Tag S.","family":"Anbar","sequence":"additional","affiliation":[{"name":"Department of Dermatology, STDs and Andrology Faculty of Medicine Minia University Al\u2010Minya Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maysa","family":"Yehia","sequence":"additional","affiliation":[{"name":"Department of Dermatology, STDs and Andrology Faculty of Medicine Minia University Al\u2010Minya Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha T. A.","family":"Abdel\u2010Aziz","sequence":"additional","affiliation":[{"name":"Department of Dermatology, STDs and Andrology Faculty of Medicine Minia University Al\u2010Minya Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.12.031"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.12399"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.11.010"},{"key":"e_1_2_5_5_1","first-page":"80","article-title":"Vitiligo repigmentation: what\u2019s new?","volume":"2","author":"Gianfaldoni S","year":"2015","journal-title":"Glob Dermatol"},{"key":"e_1_2_5_6_1","first-page":"23","article-title":"Dermatological indications and usage\u00a0of topical corticosteroid","volume":"18","author":"Thomas J","year":"2018","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.03.046"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/2319-7250.149424"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2006.00222.x"},{"key":"e_1_2_5_10_1","first-page":"8","article-title":"Assessment of therapeutic response in skin pigment disorder treatment","volume":"1","author":"Nugroho H","year":"2008","journal-title":"Inf Technol Int Sym"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20142717"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1586\/edm.12.32"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12366"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-1214"},{"key":"e_1_2_5_15_1","first-page":"308","article-title":"Vitiligo and intralesional steroids","volume":"69","author":"Vasistha L","year":"1979","journal-title":"Indian J Med Res"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2014.13091264"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1963.01590240144024"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.142483"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.15940","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijd.15940","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.15940","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T08:39:29Z","timestamp":1700210369000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.15940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,13]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/ijd.15940"],"URL":"https:\/\/doi.org\/10.1111\/ijd.15940","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,13]]},"assertion":[{"value":"2021-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}