{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:19:16Z","timestamp":1789010356889,"version":"build-2803163510"},"reference-count":13,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T00:00:00Z","timestamp":1636329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Juvenile nasopharyngeal angiofibroma (JNA) is a rare but potentially life\u2010threatening fibrovascular tumor that is seen almost exclusively in adolescent males and usually presents with symptoms of nasal obstruction or severe epistaxis. The current gold standard of treatment consists of complete surgical resection; however, this is inherently challenging because of the tumor\u2019s invasive nature and a substantial risk of intraoperative hemorrhage. Flutamide, an anti\u2010androgen antineoplastic agent, has been used preoperatively in attempts to reduce tumor volume allowing for surgical resection with more conservative procedural techniques and reduce intraoperative blood loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A literature review of PubMed and CINAHL was used to identify and analyze 29 male patients with JNA to determine the efficacy of the preoperative use of flutamide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our analyses indicate that flutamide may be effective as a neoadjuvant agent by reducing tumor volume prior to resection in some patients but seemed to be more effective in the early stages of JNA without advanced tumor invasion. However, individual tumor response to flutamide was variable. Additionally, postpubertal patients seemed to demonstrate a greater reduction in tumor volume with flutamide compared to their prepubertal counterparts. Dosing regimen and side effects associated with flutamide therapy are also discussed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Flutamide may be an effective neoadjuvant therapy in some cases of juvenile nasopharyngeal angiofibroma, but larger scale, case\u2010control studies are likely needed to further expand on this conclusion. Postpubertal males with early\u2010stage disease seemed to be the population that may benefit most from this treatment protocol.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.15966","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T15:12:35Z","timestamp":1636384355000},"page":"1346-1352","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The use of flutamide for the neoadjuvant treatment of juvenile nasopharyngeal angiofibroma: a review of the literature comparing results by pubertal status and tumor stage"],"prefix":"10.1111","volume":"61","author":[{"given":"Graison","family":"Sitenga","sequence":"first","affiliation":[{"name":"Division of Education Creighton University School of Medicine  Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Granger","sequence":"additional","affiliation":[{"name":"Division of Education Creighton University School of Medicine  Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiffer","family":"Hepola","sequence":"additional","affiliation":[{"name":"Division of Education Idaho College of Osteopathic Medicine  Meridian ID USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna","family":"Aird","sequence":"additional","affiliation":[{"name":"Division of Dermatology Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter T.","family":"Silberstein","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Creighton University School of Medicine  Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20775"},{"key":"e_1_2_8_3_1","first-page":"21","article-title":"Juvenile angiofibroma: current management strategies","volume":"79","author":"Safadi A","year":"2018","journal-title":"J Neurological Surg"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24696"},{"key":"e_1_2_8_5_1","first-page":"14","article-title":"Nasopharyngeal angiofibroma: our experience and literature review","volume":"17","author":"Martins M","year":"2013","journal-title":"Int Arch Otolaryngol"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1309\/W5CM3A3NH7P4F5P2"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199206000-00009"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21667"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2018.07.288"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.01.007"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199409000-00013"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016486609127052"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19800801)46:3<547::AID-CNCR2820460321>3.0.CO;2-S"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198004000-00009"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.15966","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijd.15966","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.15966","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T14:51:55Z","timestamp":1692456715000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.15966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,8]]},"references-count":13,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1111\/ijd.15966"],"URL":"https:\/\/doi.org\/10.1111\/ijd.15966","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,8]]},"assertion":[{"value":"2020-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}