{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T02:31:06Z","timestamp":1789525866946,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Eosinophilic ulcer of the oral mucosa is a benign, reactive, self\u2010limited lesion. Its pathogenesis is unclear, and it clinically manifests as a punched\u2010out ulcer with surrounding indurated border, raising suspicion for a possible malignancy. On histology, an acute and chronic dense inflammatory infiltrate can be appreciated, which can extend to the deep underlying tissue (including skeletal muscle). Eosinophils are especially conspicuous on hematoxylin and eosin staining and might play an important role in the development of the ulcer. Removal of possible triggers followed by monitoring and possible biopsy are among the initial recommendations. Most lesions heal spontaneously without the need for intervention. This review aims at assisting dermatologists to easily recognize this entity, avoiding unnecessary interventions and apprehension.<\/jats:p>","DOI":"10.1111\/ijd.15986","type":"journal-article","created":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T12:24:59Z","timestamp":1637670299000},"page":"1359-1363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Eosinophilic ulcer of the oral mucosa: An update on clinicopathologic features, pathogenesis, and management"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0243-3921","authenticated-orcid":false,"given":"Lamiaa","family":"Hamie","sequence":"first","affiliation":[{"name":"Department of Dermatology American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Hamie","sequence":"additional","affiliation":[{"name":"Dentistry Beirut Arab University  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazen","family":"Kurban","sequence":"additional","affiliation":[{"name":"Department of Dermatology American University of Beirut Medical Center  Beirut Lebanon"},{"name":"Division of Genomics and Translational Biomedicine College of Health and Life Sciences Hamad Bin Khalifa University  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ossama","family":"Abbas","sequence":"additional","affiliation":[{"name":"Department of Dermatology American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,23]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"172","article-title":"Traumatic ulcerative granuloma with stromal eosinophilia. A case report and short literature review","volume":"62","author":"Marsza\u0142ek A","year":"2011","journal-title":"Polish J Pathol"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)91810-8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181e26db0"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1997.tb01047.x"},{"key":"e_1_2_9_6_1","first-page":"E28","article-title":"Traumatic ulcerative granuloma with stromal eosinophilia: a malignant\u2010appearing benign lesion","volume":"100","author":"Butler JN","year":"2017","journal-title":"Cutis"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-019-1736-z"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-017-0804-3"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2009.01371.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(93)90429-8"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1309\/AFHA406GBT0N2Y64"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2008.01444.x"},{"key":"e_1_2_9_13_1","first-page":"57","article-title":"Familial dysautonomia with Riga\u2010Fede's disease: report of case","volume":"54","author":"Rakocz M","year":"1987","journal-title":"ASDC J Dent Child"},{"key":"e_1_2_9_14_1","first-page":"Zd07","article-title":"Traumatic ulcerative granuloma with stromal eosinophila: a case report and review of pathogenesis","volume":"10","author":"Sharma B","year":"2016","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_9_15_1","first-page":"11","article-title":"Eosinophilic ulcer of oral mucosa: a case report","volume":"3","author":"Bortoluzzi MC","year":"2012","journal-title":"Ann Stomatol"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.15986","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijd.15986","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.15986","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T14:52:00Z","timestamp":1692456720000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.15986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,23]]},"references-count":14,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1111\/ijd.15986"],"URL":"https:\/\/doi.org\/10.1111\/ijd.15986","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,23]]},"assertion":[{"value":"2021-05-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}