{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:58:29Z","timestamp":1791471509901,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T00:00:00Z","timestamp":1639353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is a paucity of data regarding demodicidosis\u2010associated facial hyperpigmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To delineate the clinical, dermoscopic, and histopathologic features of demodicidosis\u2010associated facial hyperpigmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical and diagnostic data were collected from the medical files of patients who were referred to our outpatient dermatology clinic in 2006\u20132019 for evaluation of facial hyperpigmentation and were diagnosed with demodicidosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cohort included 19 patients (13 male) aged 42\u201376\u2009years, all with Fitzpatrick skin type 3\u20134. All presented with mostly asymptomatic dusky, brown\u2010gray, facial pigmentation, localized or diffuse with background erythema in 36.8% of cases, and skin roughness in 26.3%. Dermoscopy yielded characteristic findings of white gelatinous or opaque protrusions from hair follicles or infiltration of follicular openings with an amorphic material. A specific finding was perifollicular and reticulated pigmentation of the affected areas. Findings were confirmed on microscopic (<jats:italic>n<\/jats:italic>\u2009=\u20097) and histopathologic (<jats:italic>n<\/jats:italic>\u2009=\u20095) studies. Anti\u2010demodectic treatment led to complete (73.6%) or partial (23.4%) resolution of pigmentation within 2\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We describe unique clinicopathological and dermoscopic findings associated with an under\u2010recognized type of facial hyperpigmentation caused by demodex for which we propose the term \u201cpigmented demodicidosis.\u201d Demodicidosis should be added to the list of causes of facial hyperpigmentation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.15992","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T11:52:59Z","timestamp":1639396379000},"page":"564-569","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Pigmented demodicidosis \u2010 an under\u2010recognized cause of facial hyperpigmentation"],"prefix":"10.1111","volume":"61","author":[{"given":"Hana","family":"Feuerman","sequence":"first","affiliation":[{"name":"Division of Dermatology Rabin Medical Center \u2013 Beilinson Hospital Petach Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihi","family":"Atzmony","sequence":"additional","affiliation":[{"name":"Division of Dermatology Rabin Medical Center \u2013 Beilinson Hospital Petach Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirit","family":"Glick","sequence":"additional","affiliation":[{"name":"Division of Dermatology Rabin Medical Center \u2013 Beilinson Hospital Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shany","family":"Sherman","sequence":"additional","affiliation":[{"name":"Division of 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Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2008.00384.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-016-0239-8"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12536"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.01.036"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.01.035"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-59715-2"},{"key":"e_1_2_6_8_1","first-page":"294","article-title":"Demodex mites as a cause of human disease","volume":"76","author":"Elston 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Giorn Ital 1898: 205\u2014brief abstract: Br J Derm 1899: 42. Also referenced in: De Amicis T.Demodex folliculorume ipercromia cutanea. G. Ital. Malatta Venereol Pelle 1918;33:205. 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